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Palonosetron Metabolization

Palonosetron is an anti-emetic drug (reduces nausea and vomiting) that has recently been approved by the FDA ("Food and Drugs Administration Agency"). It is often used to treat the symptoms of nausea after chemotherapy.

This antiemetic drug acts as a selective high affinity antagonist of the serotonin (5-HT3) receptor.

The most common side effects are headache (9%), constipation (5%), dizziness and diarrhea. There is a risk of serotonergic syndrome if palonosetron is administered concomitantly with SSRI and NRTI drugs.

BRAND NAME

  • Aloxi ®

Gene or region studied

  • CYP2D6
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