How does pharmacogenetic information help me?
Pharmacogenetics is used for prescribe the right drug for each person, thus avoiding unnecessary side effects, allowing dose adjustments if required and selecting the drug that is most effective for each person.
Pharmacogenetics is the key to the implementation of personalized medicine.
The pharmacogenetics items are divided into “Metabolization” and “Response” for each drug.
The genetic variants in the metabolization genes that a person presents allow us to determine if the drug will produce side effects and then the doctors can adjust the recommended dose. These variants are found in the genes that metabolize drugs in the liver, and a person can be a Normal Metabolizer (EM), Poor Metabolizer (PM) or Ultra-Rapid Metabolizer (UM) for each drug. Being a Poor Metabolizer indicates that the person presents some genetic variants that makes the metabolization gene of that drug work poorly and therefore it accumulates for longer in the body, which may lead to side effects; in these cases it is recommended to reduce the dose or change medication. Being Ultrafast Metabolizer can produce the opposite effect, being convenient to increase the doses or change the treatment.
The genetic variants of “Response” are located at the target genes of the drug and allow us to know if that drug is going to be effective or not for each person, allowing teh doctors to decide if a change in the medication would be appropriate.
Pharmacogenetics is, without doubts, one of the most immediate and important benefits that arise from obtaining your results. Furthermore, the information provided is based on the recommendations made by the FDA, the EMA and other prestigious pharmacogenetics institutions, such as the CPIC (“Clinical Pharmacogenetics Implementation Consortium”)