Why in the section of polygenic diseases, do up and down arrows appear? Why do no concrete data appear?
The part of the test that assesses the predisposition to complex or polygenic diseases estimates how many times the risk of developing them increases or decreases compared to the average risk of the population thanks to the use of complex calculations based on the single nucleotide polymorphisms or SNPs analysed, the incidence of the disease, gender and the frequencies of variations in the different populations.
The arrows indicate that there is an increased, reduced, or similar predisposition to the population average in those diseases where a numerical value of “your risk” is not given.
In those diseases in which “research status” is below 100%, a value of your risk is not given because there is not as much scientific evidence and/or the number of markers included in the estimation is less than six.
It is important to consider that the risk of polygenic diseases may explain some of the variability observed between individuals for complex diseases that do not follow the classical type of Mendelian inheritance. Having a genetic predisposition to a complex disease, in which several genes are involved, does not mean that an individual who has this genetic risk will eventually develop the disease. Other factors such as the presence of other pathologies and lifestyle may contribute, to a greater or lesser extent, to the risks of developing certain conditions.