Eosinophilic esophagitis (EoE)
The esophagus is a muscular conduit that contracts to convey food from the pharynx (mouth) to the stomach. Eosinophilic esophagitis is a chronic inflammatory disorder of the tissue of the esophagus characterized by the build-up of large numbers of white blood cells called eosinophils.
Esosinophils are a special type of white blood cells or leucocytes that help fight off inflammation. They are involved in allergic illnesses such as rhinitis, atopic dermatitis, or bronchial asthma, and form part of the normal structure of certain organs of the digestive tract. In normal conditions, esosinophils are not found in the esophagus. Food allergies are secondary clinical conditions to food intake, contact or inhaling of food that trigger an inadequate immune response of the body.
There are various reasons why eosinophilic esophagitis has been linked to an allergic alternation where diverse foods or even environmental substances such as pollens and other inhaled allergens produce an inflammation after contact with the immunologic system of the esophagus tissue. When the foods that have triggered the inflammation are eliminated from the diet, or a treatment with anti allergen medicines is followed, the illness goes into remission.
GENE OR REGION STUDIED