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Hypertriglyceridemias are metabolic disorders in which there are an excess of very low density lipoprotein (VLDL), chylomicrons or the remaining particles of both.

The etiology is varied and is a clear example of the interrelation among the favoring environmental factors and a predisposing polygenic inheritance. More rarely, hypertriglyceridemias can develop as a consequence of mutations that affect the genes involved in the catabolism of lipoproteins rich in triglycerides such as lipoprotein lipase, apolipoprotein C-II or, even more recently, apo A-V, GPHIBP-1 and LMF-1.

Hypertriglyceridemia is frequently linked to obesity, diabetes mellitus and alcohol consumption. It also constitutes one of the diagnostic criteria of the metabolic syndrome considered not as a unique illness but as a association of health problems where there is an alteration in the regulation of glucose or diabetes and/or insulin resistance also linked to two or more of the following components: high blood pressure, elevated plasma triglyceride levels and/or cholesterol, low HDL, obesity and/or increased body mass and microalbuminuria.

It is, therefore, considered as a constellation of lipid and non-lipid risk factors that can develop in a simultaneous or sequential form in the same individual as manifestations of the state of insulin resistance of a genetic origin or acquired in-utero.

Hypertriglyceridemia is considered a risk factor for cardiovascular illnesses.


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