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DISEASE STUDIES

Hypertriglyceridemia

Hypertriglyceridemias are metabolic disorders in which there are an excess of very low density lipoprotein (VLDL), chylomicrons or the remaining particles of both.

The etiology is varied and is a clear example of the interrelation among the favoring environmental factors and a predisposing polygenic inheritance. More rarely, hypertriglyceridemias can develop as a consequence of mutations that affect the genes involved in the catabolism of lipoproteins rich in triglycerides such as lipoprotein lipase, apolipoprotein C-II or, even more recently, apo A-V, GPHIBP-1 and LMF-1.

Hypertriglyceridemia is frequently linked to obesity, diabetes mellitus and alcohol consumption. It also constitutes one of the diagnostic criteria of the metabolic syndrome considered not as a unique illness but as a association of health problems where there is an alteration in the regulation of glucose or diabetes and/or insulin resistance also linked to two or more of the following components: high blood pressure, elevated plasma triglyceride levels and/or cholesterol, low HDL, obesity and/or increased body mass and microalbuminuria.

It is, therefore, considered as a constellation of lipid and non-lipid risk factors that can develop in a simultaneous or sequential form in the same individual as manifestations of the state of insulin resistance of a genetic origin or acquired in-utero.

Hypertriglyceridemia is considered a risk factor for cardiovascular illnesses.

GENE OR REGION STUDIED


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