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In neuroblastoma, the tumor cells are distributed in certain types of nerve tissue in the body, being the most common characteristic the sympathetic nervous system (part of the nervous system that controls body functions, such as heart rate and blood pressure, digestion, and levels of certain hormones) although it usually begins in the abdomen and adrenal glands.

It is unknown why the tumor develops. Neuroblastoma is most frequently diagnosed in infants and children under 5 years of age, and occurs in approximately 1 out of 100,000 children, being slightly more common in boys.

In the majority of patients, by the time neuroblastoma is diagnosed, the cancer has usually metastasized (spread). Neuroblastoma spreads most often to the lymph nodes, bones, bone marrow, liver, and in infants, skin.

Sometimes, the neuroblastoma is hereditary (passed from parents to children). This form usually develops at an earlier age than the non-hereditary neuroblastoma. In patients with hereditary neuroblastoma, the neuroblastoma usually occurs at a younger age and more than one tumor may form in the adrenal medulla.


  • LINC00340, P2RX7
  • CASC15
  • LMO1
  • BARD1