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Peripheral arterial hypertension disease (PAD)

Peripheral arterial hypertension disease (P.A.D.), also known as atherosclerosis or hardening of the arteries, is a disorder in which fatty deposits called plaques build up on the walls of the arteries that transport blood. When the arteries are healthy, they have a smooth lining that facilitates blood flow and helps to prevent the formation of clots. But, over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs. P.A.D. usually affects the arteries in the legs, but it also can affect the arteries that carry blood from your heart to your head, arms, kidneys, and stomach.

Obstructed arteries raise the risk of infarction (lack of oxygen to a tissue) in any part of the body, at which time symptoms become evident. P.A.D. is one of the most prevalent affectations and normally coexists with vascular illness in other locations.


  • CHRNA3
  • 18q119p21.32