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DISEASE STUDIES

Primary biliary cirrhosis (PBC)

Primary biliary cirrhosis (PBC) is a progressive chronic liver disease caused by damage to the bile ducts in the liver, obstructing the bile flow. Although this may slowly lead to a hepatic cirrhosis, not all patients will develop it.

Primary biliary cirrhosis is considered an autoimmune disease, in which the body turns against its own cells. Researchers think it is triggered by a combination of genetic and environmental factors, perhaps produced in predisposed persons. Women account for about 90 percent of PBC cases. It is most commonly diagnosed in patients between the ages of 35 and 60.

GENE OR REGION STUDIED


  • SPIB
  • IKZF3
  • EGF
  • 7q32.1
  • 3q25.33