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РИСК РАЗВИТИЯ СЛОЖНЫХ ЗАБОЛЕВАНИЙ

Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a malignant hematologic illness in which the bone marrow makes too many lymphocytes, but which become functionally incompetent. It is spread through the blood, bone marrow, lymphatic glands and spleen. The predominant tumor cell is the mature lymphocyte, called “monoclonal proliferation”.

Lymphocytic leukemia affects 25 – 30% of the adult leukemias. It is the most frequent in the western world where CLL type B predominates, while in the Asian countries he most frequent is type T with a worse prognosis. In Europe, the incidence is 3/100,000 inhabitants/year.

The average age for diagnosis is 60 years old and is slightly more prevalent in men than in women. A third of the patients are less than 55 at the moment of diagnosis. The diagnosis is usually because of a laboratory finding (leukocytosis with lymphocytosis) and many patients (some 40%) are asymptomatic when diagnosed.

GENE OR REGION STUDIED


  • IRF4
  • 6p21.32