Pharmacogenetics
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Pharmacogenetics is the biological discipline that studies the effect of an individual's genetic variability on his or her response to certain drugs. It offers the possibility of identifying the most effective drugs, applying the best doses and optimal concentrations of these drugs, avoiding undesirable side effects according to the genetic pattern of each individual. This will make it possible to move away from empiricism when prescribing, substantially reducing the need for hospitalization and the associated costs. When an active ingredient is administered, it is absorbed and distributed to its site of action where it interacts with its substrate (receptors and enzymes), is metabolized and then excreted. At each of these steps there could be a genetic variation with a different clinical outcome. The ultimate goal is to unravel the increasing complexity of the human genome and to understand how individual genetic variations influence drug metabolization, a challenge for the coming decades and a priority due to its important implication in clinical practice.
