General osteoarthritis

Osteoarthritis is a joint disease in which joint tissues deteriorate over time. It is the most common type of arthritis affecting mainly older people. It is very common, with a prevalence of 26% of the population over 50 years of age.

Osteoarthritis is caused by degeneration of the cartilage that cushions the ends of the bones in the joints. The function of this cartilage is to allow joint movement with virtually no friction. Among the factors that can contribute to the appearance of this pathology are:

  • Age, being more frequent from the age of 50 years.
  • Sex, since women are more prone to suffer it.
  • Obesity and overweight.
  • Joint injuries, such as those that occur when practicing sports or by accident.
  • Jobs or sports that subject the joint to repetitive efforts.
  • Bone malformations, such as legs of unequal length.
  • Certain diseases such as diabetes or hemochromatosis.

Symptoms

Although osteoarthritis can affect any joint, it is much more common in the hands, knees, hips and spine. Among the most common symptoms are:

  • Joint pain and stiffness.
  • Swelling of the area.
  • Crunching of the joint with movement.
  • Decreased joint function.
  • Presence of osteophytes, which are bony protrusions that may form around the affected joint.

Prevention

Although it is difficult to prevent the onset of osteoarthritis, there are measures that can help slow down its progression, such as:

  • Weight loss, if necessary.
  • Practicing low-impact exercise regularly.
  • Good management of diseases such as diabetes.
  • Avoid joint injuries.
  • Avoid joint injuries.
  • Avoid joint injuries.
  • Avoid joint injuries.
  • Pay attention to pain and rest the joint when required.
  • Pay attention to pain and rest the joint when required.
  • Pay attention to pain and rest the joint when required.
  • Pay attention to pain and rest the joint when required.
  • Use assistive devices (such as a cane) or physical therapy.
  • Number of observed variants

    13.5 million variants

    Number of risk loci

    27 loci

    Genes analyzed

    ANAPC4 CDC5L CHMP1A COL11A1 COL27A1 CPSF6 CRADD FAM53A FAM83C GLIS3 H2BC4 HLA-DPA1 ILF3 KIF26B LMAN1L MPPED2 MTRFR PPP1R3B RAB28 RABGAP1L RAPH1 RASGRP3 SLC25A13 SLC39A8 TGFA TMEM241 TSKU ZC3H11B

    Bibliography

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