Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children under 16 years old and a significant cause of childhood morbidity. It causes persistent joint pain, inflammation, and stiffness that can last from months to years.
Juvenile idiopathic arthritis
Juvenile idiopathic arthritis is an autoimmune disease in which the immune system attacks joint tissues. The cause of the disease is currently unknown, although it is believed to be due to a combination of genetic and environmental factors.
Regarding environmental risk factors, the following have been described: infectious and vaccination history, psychological stress, maternal smoking during pregnancy, or trauma, although the evidence is still very limited.
Symptoms
In general, the disease has a slow onset. Symptoms usually begin with occasional limping and morning stiffness that improves throughout the day. As the disease progresses, the affected joints appear swollen, warm to the touch, with limited movement and/or pain on palpation. However, it is important to note that there are several types of JIA with characteristic joint involvement.
In some cases, the onset of JIA is sudden with visceral involvement, causing a general condition that includes high fever, rash, lymph node inflammation, and hepatosplenomegaly, among others.
Prevention
At present, there is no way to prevent the onset of juvenile idiopathic arthritis. Once diagnosed, the management of the disease involves a combination of medications and a healthy lifestyle, which includes a balanced diet, healthy exercise, and adequate rest.
13.5 million variants
13 loci
Bibliography
López-Isac E, Smith SL, Marion MC, et al. Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms. Annals of the Rheumatic Diseases. 2021 Mar;80(3):321-328.
Juvenile idiopathic arthritis. Mayo Clinic [Oct 2022]
Urbaneja Rodríguez E. and Solís Sánchez P. Artritis idiopática juvenil. Pediatr Integral 2017; XXI (3): 170–182.