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Selective deficiency of IgA

Selective deficiency of IgA is an immune deficiency disorder present from birth of a low or absent level of a blood protein called immunoglobulin A. Since this is one of the principal antibodies or defenses in the body's immunologic system, it is considered an immunodeficiency (disorder caused by a fault in the immune system) and is one of the most common in this group of dificiencies.

Selective deficiency of IgA is passed on through families by different inherited traits. It is found in approximately 1 in 700 individuals of European origin.

Symptoms

In itself, selective deficiency of IgA does not provoke symptoms Many people with selective IgA deficiency have no symptoms or relatively common symptoms and do not receive treatment for it. Nevertheless, important illnesses may appear in cases of selective deficiency of IgA .

The absence of IgA causes the organism to be more susciptible to diverse problems such as recurrent infections (bronchitis, conjunctivitis (eye infection), mouth and skin infections, otitis media (middle ear infection), pneumonia, sinusitis, upper respiratory tract infections); allergies, chronic diarrhea; or autoimmune illnesses such as rheumatoid arthritis, lupus or celiac disease.

Prevention

Selective deficiency of IgA is an inherited disorder and cannot be prevented if the genes responsible for the illness are inherited. Therefore, it is important to follow the recommendations for preventing the infections that might appear.

Gene or region studied

  • HLA-DQA1
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