Insomnia

Insomnia refers to a chronic sleep disorder that involves difficulties in falling or staying asleep, and goes beyond sporadic sleep disturbances. This problem can have a significant impact on the quality of life and daily functioning of those who suffer from it. In fact, it is estimated that about one third of the general population has experienced insomnia at some point in their lives.

Insomnia refers to a sleep disorder that encompasses a variety of difficulties related to the quality and quantity of nighttime rest. Affected individuals may experience problems falling asleep at the beginning of the night, difficulty staying asleep during the course of the night, or feeling that the sleep obtained is not restorative. These difficulties persist despite having an environment conducive to sleep. A central feature of insomnia is that these sleep disturbances are associated with functional impairment during the day, which may include difficulties in concentration, mood and overall performance. In addition, the pattern of sleep difficulties must be repeated at least three times per week and have been present for a minimum period of one month.

This disorder has been linked to increased risk and severity of metabolic, cardiovascular, neurodegenerative, and mental and emotional health disorders.

In the study of insomnia, genetics plays an important role, however, there are other non-genetic factors that increase the risk of suffering from this condition:

  • The female sex has a greater predisposition to suffer from insomnia due to hormonal changes experienced during the menstrual cycle, menopause or pregnancy.
  • Stress and/or traumatic life events.
  • Advanced age. There is an increased risk of insomnia after the age of 60.
  • Comorbid medical and psychiatric conditions such as anxiety, diabetes or cancer.
  • Lack of a regular sleep schedule.

Prevention of insomnia is based on the adoption of good sleep habits that promote healthy rest. Maintaining a regular bedtime and wake-up routine, even on weekends, along with regular physical activity, is a key strategy for improving sleep quality. Review of medications with possible implications for insomnia, moderation or avoidance of daytime naps, as well as limiting caffeine, alcohol and nicotine intake, also play an essential role in prevention.

Number of observed variants

13.5 million variants

Number of risk loci

242 loci

Genes analyzed

TGFBI TRPC7 PCDH1 GRIA1 TENM2 RNF130 RNF144B OR12D2 MRPS18B SFTA2 MICB ZBTB9 UQCC2 TAF11 MDGA1 BTBD9 FRS3 EPHA7 FAXC ASCC3 LIN28B NKAIN2 CITED2 SAMD5 PRKN ELFN1 SDK1 NDUFA4 DNAH11 VWC2 ZNF804B PRKRIP1 HBP1 DNAJB9 FOXP2 MDFIC KCND2 CHCHD3 SLC35B4 PTN PRSS55 PURG UNC5D CA8 TERF1 TMEM64 UBR5 CSMD3 TRPS1 GLIS3 DMAC1 NFIB RORB TLE4 PHF2 TLR4 PDCL QRFP MED27 LHX3 EXD3 SKIDA1 MTRNR2L5 ADO DUSP29 LRMDA PIK3C2A SYT13 FAM180B OR9Q1 CHRM1 CNIH2 RBM4 PDE2A RAB6A CCDC90B GRM5 CNTN5 SORL1 PTMS ADAMTS20 NAB2 HMGA2 SLC6A15 MVK KSR2 SBNO1 OLFM4 DIAPH3 PCDH20 PCDH9 SLITRK1 HS6ST3 TEX29 NPAS3 RASGRP1 TCF12 MAP2K1 INSYN1 GOLGA6A POLG FES IGF1R RHOT2 C16orf72 SNX29 GPRC5B GPR139 TAOK2 SALL1 TOX3 GNAO1 AMFR CDH8 MON1B SGSM2 MNT METTL16 RSKR DCAKD PRR15L HOXB1 IGF2BP1 CA10 TANC2 CDH2 ASXL3 DCC CCDC68 SEC11C KDM4B ZNF536 APOE ZNF784 NOL4L SRSF6 ZMYND8 STAU1 ZFP64 C20orf204 ADARB1 EP300 CSF3R C8B PDE4B NEGR1 LRRIQ3 LRRC53 PTBP2 PRMT6 MAN1A2 SERPINC1 BRINP3 IPO9 SERTAD4 MYT1L MTA3 LRPPRC NRXN1 FANCL BCL11A MEIS1 C1D LRRTM4 POU3F3 PAX8 ZEB2 ACVR2A CCDC148 MARCHF7 LNPK PLCL1 KLF7 MAP2 VWC2L GBX2 TRAF3IP1 ATP2B2 SATB1 RARB GASK1A TOPAZ1 SLC25A20 KLHDC8B UBA7 RBM5 SEMA3F FOXP1 ZNF654 IFT57 LSAMP PLCH1 RARRES1 NLGN1 ZMAT3 DNAJC19 KCNIP4 ARAP2 PRKG2 MMRN1 SLC39A8 TET2 FAM241A ARHGAP10 ISL1 KIF2A RASGRF2 TMEM161B ARRDC3 NR2F1 MACIR NUDT12 EFNA5

Bibliography

What do your genes say about you? Start your journey today.

Get a special 5% discount on your first kit.

Haven't you taken our DNA test yet?

Get your genetic test and discover what your DNA says about you.

pack
Starter DNA test
The best option to get started

Ancestry service, Traits and Wellness

Buy
pack
DNA test Advanced DNA test
Know your DNA in depth

Health, Ancestry service, Traits and Wellness

Buy
pack
Genetic analysisUltra
Whole Genome Sequencing 30x

Health, Ancestrality, Traits and Wellness

includes three months of tellmeGen+

Buy

Important information and limitations

Europe
Austria
Belgium
Czech Republic
Denmark
Finland
Germany
Hungary
Ireland
Italy
Netherlands
Norway
Poland
Portugal
Romania
Spain
Sweden
Switzerland
United Kingdom
Asia
Kazakhstan
Saudi Arabia
UAE
America
Brazil
Canada
Chile
Colombia
Mexico
Panama
Peru
United States
Oceania
Australia
BLACK FRIDAY Sale Only until November 27 Use our coupon BLACK15
Buy