The serum PSA value is useful for the follow-up and early detection of prostate cancer since the probability of developing prostate cancer increases with higher values. However, since there is no agreed cut-off point, additional tests are often required to establish the diagnosis or to rule out other causes of its increase.
PSA (Prostate Specific Antigen) Levels
Prostate-specific antigen (PSA) is an enzyme produced by prostate tissue cells whose function is to participate in the dissolution of possible clots in the seminal fluid, and therefore plays an important role in fertility. PSA is found in greater quantities in the seminal fluid, however some of it can escape from the prostate and be released into the serum.
Increased serum PSA levels are associated with prostate cancer. In fact, it has been shown to be superior to other techniques traditionally used for the detection of early prostate cancer, achieving detection rates with a specificity close to 91% when the serum PSA value reaches values above 4 ng/mL. Early prostate cancer is usually asymptomatic and an elevated serum PSA level is often the first indication of cancer. However, there is no specific normal or abnormal blood PSA concentration that can currently serve as a threshold, so an elevated PSA result would recommend a confirmatory test as well as additional tests to confirm the possible diagnosis, as PSA is the only way to confirm the diagnosis.Elevated serum PSA can also be found in a litany of benign conditions, such as infections, trauma, inflammatory processes or benign prostatic hyperplasia (BPH) that can temporarily increase levels. Likewise, decreased values may be present in positive cases of prostate cancer, so monitoring is also recommended for men over 50 years of age, or who have a family history of prostate cancer.

Genes analyzed
Bibliography
Gudmundsson J, Besenbacher S, Sulem P, Gudbjartsson DF, Olafsson I, Arinbjarnarson S, et al. Genetic correction of PSA values using sequence variants associated with PSA levels. Sci Transl Med. 2010;2(62):62ra92.
David MK et al. Prostate Specific Antigen. [May 2022]
Medscape. Prostate-Specific Antigen Testing [May 2022]
American Cancer Society. Prostate Cancer. Early detection, diagnosis, and staging [May 2022]
National Institute of Health. National Cancer Institute [May 2022]