Prostate-specific antigen (PSA) is an enzyme produced by prostate tissue cells whose function is to participate in the dissolution of possible clots in the seminal fluid, and therefore plays an important role in fertility. PSA is found in greater quantities in the seminal fluid, however some of it can escape from the prostate and be released into the serum.

Increased serum PSA levels are associated with prostate cancer. In fact, it has been shown to be superior to other techniques traditionally used for the detection of early prostate cancer, achieving detection rates with a specificity close to 91% when the serum PSA value reaches values above 4 ng/mL. Early prostate cancer is usually asymptomatic and an elevated serum PSA level is often the first indication of cancer. However, there is no specific normal or abnormal blood PSA concentration that can currently serve as a threshold, so an elevated PSA result would recommend a confirmatory test as well as additional tests to confirm the possible diagnosis, as PSA is the only way to confirm the diagnosis.Elevated serum PSA can also be found in a litany of benign conditions, such as infections, trauma, inflammatory processes or benign prostatic hyperplasia (BPH) that can temporarily increase levels. Likewise, decreased values may be present in positive cases of prostate cancer, so monitoring is also recommended for men over 50 years of age, or who have a family history of prostate cancer.

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