Sleep duration

It is now clear that genetics plays a major role in sleep traits. Although environmental factors can influence sleep duration and intensity, certain genetic variants are known to affect these traits, and in some cases can even lead to familial sleep disorders.

Sleep is defined as a reversible natural state of unconsciousness in which there is a decreased responsiveness to external stimuli and relatively low activity.

Sufficient, high-quality sleep is essential for mental and physical well-being. The American Academy of Sleep Medicine recommends a daily sleep duration, in adults, of at least 7 hours per night on a regular basis.

Unlike other mammals, sleep duration in humans is thought to be regulated by two processes: the homeostatic S-process that increases during wakefulness and dissipates during sleep and the C-process, controlled by the circadian clock that is synchronized with the Earth's day-night cycles through the secretion of melatonin. In addition, sleep duration is a process that adjusts according to needs, so that when sleep is lost, compensatory mechanisms are activated that extend the duration of subsequent sleep.

Sleep is necessary for memory consolidation and involves the incorporation of memories acquired in the hippocampus into the neocortex brain network, where their long-term storage occurs.

Chronic sleep and circadian rhythm disturbances have been associated with an increased risk of mood disturbances, lower cognitive performance and cardiometabolic disturbances. Understanding the role of genetics and the underlying biological mechanisms that trigger sleep-associated disorders is still the subject of multiple studies.

Number of observed variants

13.5 million variants

Number of loci analyzed

52 loci

Genes analyzed

ACVR2A ARRDC1 ASCL4 BANK1 BUD13 C1orf94 C2orf69 CA10 CCSER1 CHCHD3 CTSC DPYD EGR2 EPHA7 FADS1 FANCL FLRT3 GIN1 GNAO1 GTPBP1 HCRTR2 HISA6 HMX2 HMX3 HSD17B12 IL20RB IRX2 MAD1L1 MAX METTL15 MSL2 MVK NOS1 NOVA1 NR4A2 NRXN3 PABPC1L PAX8 PDE4B PFAS PIN1 RBFOX1 SCN1A SEMA6D SGCZ SKIDA1 SLC6A3 SLC8A1 SPOPL SRSF12 TENM4 ZBED9 ZCCHC7

Bibliography

Haven't you taken a DNA test yet?

Get your genetic test and find out all about yourself.

starter

Ancestry, Traits and Wellness

advanced

Health, Ancestry, Traits and Wellness

Special offer Christmas

Until December 26

-15% on our DNA tests

Use our code XMAS15