Thyroid function (TSH levels)

Thyroid dysfunction is an important health problem that affects 10% of the population, increasing, above all, cardiovascular risk. Among other parameters, in clinical practice it is evaluated by measuring TSH levels, so that an increase would be related to hypothyroidism and a decrease to hyperthyroidism.

The thyroid is a bilobed, butterfly-shaped gland located in the neck in front of the trachea. It produces thyroid hormones, thyroxine (T4) and triiodothyronine (T3), which control the body's metabolism and the balance of other hormones. Among its many functions are the regulation of body temperature, heart rate, oxygen consumption and protein synthesis, hence they are essential in growth and organogenesis.

The thyroid is finely regulated by Thyroid Stimulating Hormone (TSH) secreted by the pituitary gland. TSH stimulates the release of thyroid hormones, but these, in turn, exert a negative action on TSH production when TSH levels increase.

Thyroid dysfunction is a very common condition. Moreover, in recent years it has become clear that not only clinical hypo- and hyperthyroidism have clinical manifestations, but that subclinical ones are associated with increased risk of pathological conditions such as coronary heart disease, depression or cardiovascular disease. More recently, studies have shown that even physiological variations of thyroid hormones within the normal range would be associated with many of these complications.

Therefore, knowledge of the factors that regulate this complex hormonal system can help in taking measures to reduce the risks associated with its dysregulation.

Number of observed variants

13.5 million variants

Number of loci analyzed

20 loci

Genes analyzed

ABO ADCY9 BCAS3 C9orf92 CADM1 CAPZB DET1 DIRC3 FAM227B/FGF7 FOXA2 GATA3 GLIS3 HES1 IGF2BP2 IGFBP5 INSR ITPK1 MAF MBIP MIR365A NFIA NKX2-3 NR3C2 NRG1 NSF PDE10A PDE8B PRDM11 PRKX PSORS1C1 PTEN SASH1 SLC25A37 SOX9 SPATA13 SULF1 SYN2 TG TM4SF4 TSHR VAV3 VEGFA/LOC100132354

Bibliography

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