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Adipose tissue formation

Adipose tissue is an important site for lipid storage, energy homeostasis, and whole-body insulin sensitivity. There are two distinct classifications of adipose tissue: white adipose tissue and brown adipose tissue. White adipose tissue accounts for the majority of fat present in adult humans and brown adipose tissue predominate in postnatal babies. The formation of adipose tissue or adipogenesis is the development of fully differentiated mature adipocytes from precursor cells.

Adipogenesis occurs in two stages, first it is produced the determination of an indiferenciated cell into a preadipocyte and at a second stage the preadipocyte becomes a mature adipocyte. This process is regulated by hormones and transcription factors.

Adipocyte differentiation is closely regulated by a cascade of transcription factors that interact with the DNA and promote the expression of genes that determine the features of a mature adipocyte, amongst them the peroxisome proliferator-activated receptor gamma (PPARG).

Gene or region studied

  • PPARG
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