Epidemiological studies indicate that one out of every three adults in the world is overweight. This abnormal accumulation of fat can be detrimental to health, although its consequences are not limited to the body, as it can influence mood and affect social life.
Body mass index
The body mass index (BMI), also known as the Quetelet index, is a simple indicator of the relationship between a person's weight and height that is often used to identify overweight and obesity in adults. It is defined as a person's weight in kilograms divided by the square of the person's height in meters (kg/m2). It is a simple criterion that classifies people as underweight, normal weight, overweight and obese. These BMI ranges are based on the effect that excess body fat has on disease and are well related to adiposity.
BMI is very easy to measure and calculate, making it the most widely used tool for correlating the risk of health problems with weight at the population level. Like any other measure, it is not perfect because it only depends on height and weight and does not take into account different levels of adiposity depending on age, physical activity levels and gender. For this reason, it can be expected to overestimate adiposity in some cases and underestimate it in others.
Approximately 39% of the world's population is overweight and obese, both of which are associated with increased risk of metabolic disease. In general, individuals with a higher BMI have a higher risk of cardiometabolic diseases such as type 2 diabetes, high blood pressure, stroke or even some types of cancers. This risk increases especially if you have significant fat deposits in the abdominal area.

Number of observed variants
13.5 million variants
Number of loci analyzed
656 loci
Genes analyzed
Bibliography
Pulit S.L., Stoneman C., et al. Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Human Molecular Genetics, 01 Jan 2019, 28(1):166-174
National Heart, Lung, and Blood Institute (NIH) [April 2022]