Body mass index

Epidemiological studies indicate that one out of every three adults in the world is overweight. This abnormal accumulation of fat can be detrimental to health, although its consequences are not limited to the body, as it can influence mood and affect social life.

The body mass index (BMI), also known as the Quetelet index, is a simple indicator of the relationship between a person's weight and height that is often used to identify overweight and obesity in adults. It is defined as a person's weight in kilograms divided by the square of the person's height in meters (kg/m2). It is a simple criterion that classifies people as underweight, normal weight, overweight and obese. These BMI ranges are based on the effect that excess body fat has on disease and are well related to adiposity.

BMI is very easy to measure and calculate, making it the most widely used tool for correlating the risk of health problems with weight at the population level. Like any other measure, it is not perfect because it only depends on height and weight and does not take into account different levels of adiposity depending on age, physical activity levels and gender. For this reason, it can be expected to overestimate adiposity in some cases and underestimate it in others.

Approximately 39% of the world's population is overweight and obese, both of which are associated with increased risk of metabolic disease. In general, individuals with a higher BMI have a higher risk of cardiometabolic diseases such as type 2 diabetes, high blood pressure, stroke or even some types of cancers. This risk increases especially if you have significant fat deposits in the abdominal area.

Number of observed variants

13.5 million variants

Number of loci analyzed

656 loci

Genes analyzed

AADAT AARSD1 ABCG2 ABHD17C ACO1 ACOT12 ACVR2A ADAM10 ADAM23 ADARB1 ADCY3 ADCY9 ADGRG6 ADGRL2 ADGRL3 ADK ADSL AFF3 AGA AGAP1 AHR AK5 AKT3 ALCAM ALKBH3 ALPK1 AMFR AMH AMPD2 ANAPC4 ANKK1 ANKRD28 ANTXR2 APC APOM ARAP1 ARHGAP15 ARNTL ARPP21 ARRDC4 ASCC3 ASIC2 ASXL3 ATF7IP ATOH1 ATP11B ATP2A1 AUTS2 AXIN1 B3GAT1 BACE2 BACH1 BAIAP2 BBS4 BBX BCDIN3D BCL11A BCL11B BCL2 BDNF BEND5 BLID BMP2 BNC2 BORCS7 BPTF BRINP1 BRINP3 BRWD1 BTBD9 C12orf42 C16orf72 C8B C9orf72 CACNA1C CACNB2 CACNG3 CADM1 CADM2 CADPS CALCR CALN1 CAMK1G CAMKMT CAMKV CARD11 CASZ1 CBLN1 CBLN4 CBX4 CCDC171 CCDC6 CCDC85A CCDC92 CCER1 CCK CCND1 CCNE1 CCNL1 CDC5L CDCP1 CDH13 CDH22 CDH7 CDH8 CDH9 CDIN1 CDK11B CELA2B CELF2 CENPC CEP120 CFAP74 CHD1 CHDH CHMP3 CHORDC1 CHRNA2 CLVS1 COBLL1 COL16A1 COL19A1 CPNE4 CPNE8 CPS1 CPSF6 CRB1 CRB2 CREB1 CRH CRIM1 CRTAC1 CSMD1 CSNK1G2 CTNNA2 CTNNB1 CWC27 CXXC5 CYB5RL DCP1B DDC DGKI DHFR2 DHRS11 DHX36 DIAPH3 DLG2 DLK1 DMXL2 DNAJB2 DNAJB8 DNAJB9 DNALI1 DOK5 DPF3 DPH6 DPYD DPYSL4 DPYSL5 DUSP6 DYRK1A DYRK2 E2F3 EBF1 EBF2 ECE2 EDEM3 EFNA5 EFR3A EHBP1 EIF5A2 ELAVL2 ELFN1 ELP3 EMC3 ENTPD6 ERAP1 ERBB4 ERC2 ETAA1 ETS2 ETV5 EVI5 EXOC3L2 EXT1 FABP2 FAM135B FAM216A FAM241A FAM71C FANCL FBXL17 FBXL18 FBXO21 FBXO33 FEZ2 FEZF1 FGFR1 FGFR4 FHIP1B FHIT FIBCD1 FIGN FLT3 FOXG1 FOXO1 FOXO3 FRRS1L FSTL5 FTO GADD45G GALC GALNT16 GALNT7 GATB GIPR GJE1 GLYR1 GNAQ GNPDA2 GNRH2 GOLGA3 GP2 GPR26 GPR52 GPRC5B GRID1 GRP GSAP HACD2 HACE1 HECTD2 HEY2 HHIP HIVEP1 HIVEP2 HIVEP3 HMGB1 HNF4G HRC HRH4 HS6ST3 HSD17B12 HSPA12A HTR1A IGF1R IGF2BP1 IGSF11 IL12RB1 ILRUN INKA2 IPO9 IRF2BPL IRX1 IRX3 ISL1 ITPRID2 JADE2 JAZF1 JMJD1C KCNB2 KCNH2 KCNH5 KCNJ11 KCNJ12 KCNMA1 KCNRG KCNT2 KCTD13 KCTD15 KDM4C KDM7A KIAA1522 KIF16B KIT KLF1 KLF3 KLF7 KLHL32 KRTAP4-12 KSR2 L1TD1 L3MBTL3 LCORL LDB2 LHCGR LHX5 LINGO1 LINGO2 LMCD1 LMO3 LMX1B LRFN5 LRMDA LRP1B LRRC53 LRRC55 LRRTM1 LSAMP LYPD1 LYRM2 LYRM7 LYZL4 LZTS1 MACF1 MACROD2 MAFB MAML3 MAN1A1 MAP2K1 MAP3K3 MAPKBP1 MASP2 MAST4 MAT2B MC4R MCTP1 MCTP2 MDFIC2 MED23 MEF2C MEF2D METAP1D METTL25 METTL4 MEX3A MFAP2 MFAP3 MICALL1 MICOS10-NBL1 MLIP MMAB MMP16 MMS22L MPPED2 MRAS MRGPRD MRM1 MTIF3 MYH15 NCAM1 NDUFS3 NEDD1 NEGR1 NEK6 NFAT5 NFIB NFIL3 NFU1 NKAIN2 NKX2-4 NLGN1 NLK NLRC3 NPAS3 NPY NR2F1 NR4A2 NRG1 NRP1 NRSN1 NRXN1 NRXN3 NSFL1C NTAN1 NTM NTNG1 NTRK2 NUDT12 NUP54 NXPH4 OBI1 OLA1 OLFM1 OLFM4 ONECUT1 OPCML OPRM1 OPTC OTOL1 OTUD7A P2RX4 PA2G4 PAM PARD3B PAX2 PCDH17 PCDH18 PCDH20 PCDH7 PCDH9 PCP4 PCSK1 PCSK2 PDE1C PDE4B PDILT PDS5B PDZRN4 PEPD PGPEP1L PHF2 PHTF2 PIK3R3 PKDCC PLCG2 PLEKHA5 POC5 POU3F3 POU6F2 PPARG PPP1CB PPP1R3A PPP2R3C PRDX5 PRELID2 PREX1 PRICKLE4 PRKCB PRKD1 PRKG1 PRKN PRMT6 PRMT7 PRPH2 PRR16 PRR20C PRRC2C PSAT1 PTBP2 PTP4A1 PTP4A3 PTPN7 PTPRD PTPRG PURG RAB27B RAC1 RALY RALYL RANBP17 RARB RASA2 RASGRF1 RBBP6 RBFOX1 RBM19 RBMS1 RCAN2 RCN1 RELN RERE REXO1 RFTN2 RGS12 RGS17 RIT2 RMC1 RMDN1 RNF144B ROBO1 ROBO2 RORA RPAIN RPL10L RPL32 RPS6KA5 RPTOR RSU1 RTL1 RTN4 RTN4RL1 SALL3 SALL4 SCLT1 SCN2A SCYL1 SDK2 SEC16B SEC61B SEMA6D SETBP1 SETD5 SGCZ SGO1 SHOX2 SIGLECL1 SIK3 SKAP2 SKIDA1 SKOR1 SKOR2 SLC10A2 SLC10A7 SLC14A2 SLC16A3 SLC16A7 SLC22A3 SLC25A37 SLC39A8 SLC5A11 SLCO3A1 SLF2 SLIT2 SLITRK6 SMARCAD1 SMCO4 SMG6 SMIM30 SNX19 SOCS5 SOX11 SOX2 SOX4 SOX5 SP1 SPACA3 SPAG17 SPATA19 SPDYE17 SPDYE5 SPHKAP SQOR SRSF1 SRSF6 SSH2 SSR3 STAG1 STIM2 STK24 STXBP6 SWI5 SYCE1L SYT14 SYT16 SYT3 TAFA5 TAL1 TBC1D7 TBX15 TCEA2 TCF7L2 TECRL TEX29 TEX46 TFAP2B TGFBRAP1 TH THAP3 THUMPD2 TIGIT TLE1 TLE4 TLR4 TM6SF2 TMEFF2 TMEM160 TMEM18 TMEM182 TMEM196 TMEM60 TNIK TNRC6C TOMM40 TRAF3 TRIB1 TRIB2 TRIM47 TRIM66 TRIP12 TRPM3 TRPS1 TSKU TSNARE1 TTC19 TTC34 TTLL4 TUSC3 UBASH3B UBE2E3 UBE2R2 UBE2W UBE3D UBXN7 UNC5C UNC5D UNC79 USP46 VAMP3 VEGFA VGF VGLL4 VIRMA VPS11 VPS13C VWC2 WDR12 WNK1 WSCD2 XKR6 XRCC3 XXYLT1 YTHDF3 YWHAZ ZBTB10 ZBTB7A ZBTB7C ZC3HAV1 ZCCHC7 ZCCHC8 ZEB2 ZFP64 ZFPM2 ZMIZ2 ZNF131 ZNF394 ZNF462 ZNF536 ZNF608 ZRANB1 ZSWIM

Bibliography

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