Vitamin D levels

Vitamin D is an essential nutrient for the maintenance of our health. Its main function is the regulation of calcium and phosphate levels, so it has a nutritional role in the maintenance of healthy bones and teeth.

Vitamin D is produced in the human skin from 7-dehydrocholesterol by the action of UVB rays. This vitamin D is biologically inactive and needs to be metabolized to produce different compounds that are active and responsible for multiple functions in the body.

When UV rays come into contact with the skin, 7-dehydrocholesterol is transformed into cholecalciferol or vitamin D3. This, which is actually a prohormone, is biologically inactive. To be functional, it must undergo two transformations, the first in the liver forming calcidiol or 25-hydroxycholecalciferol and the second in the kidney forming calcitriol or 1-alpha-25-hydroxycholecalciferol which is the active form.

The main function of vitamin D is the regulation of calcium and phosphorus homeostasis, however, in recent years, many other unrelated functions have been identified in the immune, endocrine, neuromuscular or hematopoietic systems. Beneficial effects of vitamin D consumption have even been observed in some diseases such as rheumatoid arthritis or multiple sclerosis.

The vitamin D needed by the body comes from two sources: synthesis in the skin in the presence of sunlight and the intake of foods that contain it. In the human species, the main source is skin synthesis and a smaller proportion depends on food. However, there are external agents that can hinder this cutaneous synthesis, such as latitude, advanced age and dark-colored skin, and in these cases it is important to guarantee an adequate intake.

There are very few foods that contain vitamin D naturally, being fatty fish such as salmon or trout the richest in this compound, in addition to fish liver oil which is the richest source. Nowadays, we can find many foods fortified with vitamin D.

Number of observed variants

13.5 million variants

Number of loci analyzed

39 loci

Genes analyzed

ADAMTS3 ADH1B ALDH1A2 APOA5 APOB APOE C2orf16 CETP COX18 CYP24A1 DNAH11 DOK7 DYDC2 ENPP3 FGFBP1 FOXO6 GC HAL HDGFL1 HTR4 KLK11 KRTAP5-7 LCE3E LDLR MAF MIA2 NRIP1 PADI1 RRAS2 S100A11 SDR42E1 SLCO1B1 SULT2A1 TM6SF2 TSKU UGT1A5 UGT2A3 UGT2B4 USP3 ZPR1

Bibliography

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