Cabozantinib response and medullary thyroid cancer
Cabozantinib is a small molecule that inhibits several tyrosine kinase receptors involved in tumor growth and angiogenesis, pathologic bone remodeling and metastatic cancer progression. Cabozantinib is used in the treatment of patients with progressive metastatic medullary thyroid cancer.
Medullary thyroid cancer (MTC) is a form of thyroid carcinoma which originates parafollicular cells of the thyroid gland (C cells), which produce the hormone called calcitonine. Medullary tumors are the third most common of all thyroid cancers; they are about 3% of all thyroid cancer cases.
Biochemical markers currently used for the diagnosis and monitoring of the disease are serum concentration of calcitonine and carcinoembryonic antigen.
To the date, surgery and radiation therapy have been the major treatments for medullary thyroid carcinoma, but today oncologists consider the treatment with TKIs (tyrosin-kinase inhibitors) as cabozantinib.
One of the prognosis markers for the response to cabozantinib in patients with MTC is the presence of the M918T RET mutation (RET+ patients). RET is a tyrosine kinase receptor which mutation is involved in pathologic processes such as oncogenesis, metastasis, angiogenesis, and maintenance of the tumor microenvironment.
Cabozantinib is administered orally and the recommended daily dose of 140 mg (divided in one 80 mg shot and three 20 mg capsules).
The treatment is continued until the progression of the disease occurs or if there is a risk due to the toxicity of the drug.
Gene or region studied