Allergic rhinitis

Allergic rhinitis is a set of symptoms affecting the nose and sinuses. It is usually triggered by allergens such as dust, dust mites or cat and dog hair. It is a very common disorder, affecting between 20-40% of the global population.

The most important risk factor for allergic rhinitis is the genetic component. Having a first-degree relative affected can increase the probability of suffering from allergic rhinitis by up to 75%.

However, in addition to the above, there are several environmental factors that also contribute to its development, among which the following stand out:

  • Having allergies or asthma.
  • Suffering from atopic dermatitis or eczema.
  • Living in an environment of continuous exposure to allergens, smoke or odors that irritate the nasal epithelium.
  • Having a mother who smoked during pregnancy and/or first year of life.

Symptoms

It is usually a chronic condition with symptoms that may appear continuously or be seasonal, triggered by exposure to allergens (pollen, dust mites, pet hair, etc). Symptoms include:

  • Runny nose and nasal congestion.
  • Itching and redness of the eyes
  • Coughing and sneezing
  • Itchy nose and throat
  • Bluish or swollen skin under the eyes
  • Difficulty sleeping and tiredness

Prevention

There is no effective way to prevent the development of allergic rhinitis, although there is a way to reduce the symptoms by avoiding exposure to triggering allergens and taking appropriate medications for its control.

Number of observed variants

13.5 million variants

Number of risk loci

35 loci

Genes analyzed

ADAD1 ALOX15 APOBR BCL6 CBLN1 CD247 CRTC3 CXCR5 EMSY EYA2 FCER1G GAL3ST2 GATA3 ICE2 ID2 IKZF3 IL18R1 IL33 IL7R ITGB8 LRRC32 MSX1 MYC PTTG1 RFTN2 RMI2 RPS26 SLC7A10 SMAD3 SMARCE1 TLR10 TMEM232 TSLP UQCC2 WDR36

Bibliography

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