Hemorrhoids or piles are swollen veins in the anus and lower rectum, similar to varicose veins, that can develop internally or externally. They usually cause pain and/or bleeding, and their prevalence is highly variable depending on age, ranging from 5% to 36%.
Haemorrhoidal disease
Hemorrhoids are physiological structures made up of arteriovenous vascular plexuses that form a cushion along the anal canal. When pressure increases in these areas, these hemorrhoids swell, causing hemorrhoidal disease. The factors that can favor their development include:
- Age, as tissues can weaken over the years.
- Straining during bowel movements.
- Sitting for long periods on the toilet.
- Chronic diarrhea or constipation, for example, in the case of irritable bowel syndrome.
- Obesity.
- Pregnancy.
- Low-fiber diet.
- Performing physical exertion regularly.
Symptoms
The symptoms of hemorrhoids can vary depending on the type.
- External hemorrhoids: located in the anus, they can cause swelling in this area, itching, pain, and/or bright red bleeding.
- Internal hemorrhoids: located inside the rectum, they are usually asymptomatic. If discomfort occurs, it includes pain and/or bright red bleeding.
- Thrombosed hemorrhoids: occasionally, blood can accumulate inside the vessel (thrombus) and cause severe pain, inflammation, and the presence of a hard lump near the anus.
Prevention
The most effective way to prevent the development of hemorrhoidal disease is to maintain a soft consistency of the stools. To achieve this, it is advisable to eat foods rich in fiber such as fruits, vegetables, and whole grains, drink plenty of fluids, or consider adding fiber supplements.
Additionally, avoiding an increase in pressure in the anal and rectal area can also prevent its development. In line with this, it is advised not to strain during bowel movements and not to sit on the toilet for long periods.
Furthermore, regular exercise prevents constipation and overweight.
Number of observed variants
13.5 million variants
Number of risk loci
103 loci
Genes analyzed
Bibliography
Zheng T, Ellinghaus D, Juzenas S, et al. Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Gut. 2021 Apr:gutjnl-2020-323868.
Hemorrhoids. Mayo Clinic [Dec. 2021]
Sun Z, Migaly J. Review of Hemorrhoid Disease: Presentation and Management. Clin Colon Rectal Surg. 2016 Mar;29(1):22-9.
Hemorrhoids. National Institute of Diabetes and Digestive and Kidney Disease.