C-reactive protein levels

C-reactive protein is a protein commonly used to determine the degree of effectiveness of a treatment as it is linked to the immune system and participates in the defense system against infections.

C-reactive protein (CRP) is a protein synthesized by the liver, the level of which increases in response to inflammation. CRP is an acute phase reactant protein that is mainly induced by the action of interleukin 6 on the gene responsible for CRP transcription during the acute phase of an inflammatory process.

Although CRP is mainly synthesized in hepatic hepatocytes as mentioned above, it can also be synthesized in smooth muscle cells, macrophages, endothelial cells, lymphocytes and adipocytes.

The name CRP arose because it was first identified as a substance in the serum of acutely inflamed patients that reacted with the antibody to the "C" carbohydrate of the pneumococcal capsule.

CRP has both proinflammatory and anti-inflammatory properties. It plays a role in the recognition and elimination of foreign pathogens and damaged cells by binding to phosphocholine, phospholipids, histone, chromatin and fibronectin, enhancing macrophage phagocytosis and participating in innate immunity as a first defense system against infections.

There are many factors that can alter initial CRP levels, such as age, sex, smoking, weight, lipid levels and blood pressure.

CRP levels increase and decrease rapidly with the onset and removal of the inflammatory stimulus, respectively. Normal C-reactive protein levels increase within 6 hours and peak within 48 hours. Persistently elevated CRP levels may be seen in chronic inflammatory conditions, such as chronic infections or inflammatory arthritis, such as rheumatoid arthritis.

Measuring and quantifying the level of C-Reactive Protein can be useful in determining the effectiveness of a treatment or knowing how advanced a disease or infection is.

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Number of observed variants

13.5 million variants

Number of loci analyzed

91 loci

Genes analyzed

ABO ACKR1 ADAP1 ANK3 APOC1 APOLD1 ARNTL BDNF BMP8A C2orf16 C2orf74 CCDC171 CENPW CEP112 CH25H CRK CRP CTSB CYP3A7 DHRS9 DPF3 DUSP1 FZD9 GIMAP7 GPR4 H3-5 HNF1A HNF1B HNF4A HNRNPA1P48 HPN ICE2 IKZF2 IL1F10 IL4R IL6R IRS2 ITGA1 LAMP1 LYZ MAF MAFB MALSU1 MAPRE3 MC4R MROH6 MYBPC3 MYC NCF1 NDST2 NIPAL4 NLRP3 NYNRIN OLIG3 ONECUT1 ONECUT2 OR4A15 OR4A47 OR4A5 OR4C13 PCIF1 PDE4B PPP1R3B PPP2R2D PSMG1 PTPN1 RAB26 RAVER2 RBKS RNF146 RPGRIP1L RPS6KB1 SEPTIN2 SGIP1 SLC9A3R1 SOCS3 SOX5 STEAP1B STRN TFEB THRB TM6SF2 TMEM18 TNFRSF6B TRAIP TRIB1 USP44 UVRAG WDR72 YIPF2 ZNF112 ZNF644

Bibliography

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