Cognitive ability

The study of genetic variants can help us understand the causes of differences in the cognitive functions of individuals that are determined by the environment but also have an important contribution from genetics.

Educational attainment appears to be genetically influenced and was the main subject of the first GWAS (genome-wide association study) applied to the social sciences that looked for which genes might be related to such cognitive ability.

Cognitive ability is fundamental to physical and mental well-being. Better cognitive function during youth is associated with a lower risk of psychiatric disorders and disease later in life. Conversely, there is evidence that some diseases can affect cognitive abilities in young people, thereby affecting their studies.

Number of observed variants

13.5 million variants

Number of loci analyzed

176 loci

Genes analyzed

ABT1 ADAMTSL3 AFF3 ANAPC4 ARHGAP15 ARID1B ARPP21 ARRDC3 ARTN ATXN7L2 AUTS2 BCL11A BCL11B CACNA1E CADM2 CALN1 CCDC134 CDH8 CDH9 CENPC CHORDC1 CHRAC1 CLCN2 CLNK CLSTN2 CNTNAP4 COL11A1 CRYBA4 CSE1L CYLD CYSTM1 DAOA DBN1 DDX18 DEPDC1 DHRS11 DLC1 DLL4 DNAJB6 DPP4 DPYD EEA1 EFL1 ELAVL2 ERBB4 ERLIN1 FAM120AOS FAM180B FAM189A2 FAM76B FBXL4 FGGY FOXA2 FOXO3 FOXO6 FOXP1 FSIP2 GAD1 GALNT16 GALNT17 GALNT3 GATB GPD2 GTDC1 HHLA2 HNRNPA1P48 HSD17B3 HYI IER5L IGDCC4 IGF2BP1 IGSF9B IL20RB ITGB7 KCNH7 KCNJ3 KLC1 LMCD1 LRFN5 LRGUK LRPPRC LRRC14 LRRC4 LRRTM3 LZTS1 MACIR MAPK6 MBD2 MED27 MEF2C MGAT3 MGST2 MKI67 MTSS2 NCAPG NEGR1 NKIRAS1 NOL4L NOVA1 NPAS3 NPY NR2F1 NRBF2 OGA OPN1SW PALM PAWR PCDH17 PCGF3 PDE1C PDE4D PEF1 PKD1L3 PKDCC PKHD1 PLEKHM1 POU3F2 PPP1R3C PRKAG1 PRKD1 PRL PSMG1 PTCH1 RAB11FIP5 RALYL RBL2 RBM25 RPS23 RPS26 RRAS RUNX1T1 RWDD3 SATB2 SEPTIN3 SH2B1 SHISA9 SHISAL2B SLC27A3 SLC39A8 SLC5A11 SMIM4 SORCS3 SP4 SRPK2 STARD4 SYT7 TANC2 TECRL TENM2 TET2 THSD7B TMEM114 TMEM160 TMEM170B TMEM245 TNIP2 TRAIP TRIM37 TRIOBP TSEN2 TSHZ3 TSNARE1 TTC27 TTLL7 USH2A VRK2 WNT4 WRN ZC3H12A ZMIZ2 ZNF638 ZNF799

Bibliography

Lee J.J., Wedow R., et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 23 Jul 2018, 50(8):1112-1121.

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