Neuroticisms

Neuroticism is one of the main personality traits referring to a person`s tendency to experience negative emotions, such as anxiety, sadness, irritability and worry.

Since its introduction in the 1960s, the definition of the term neuroticism has undergone various conceptualizations. In general, it refers to the relatively stable tendency to view the world and one`s own life negatively and to respond with negative emotions to threatening experiences, frustration or loss. Despite the difficulty in conceptualizing neuroticism, there seems to be a consensus that the main characteristic would be the tendency to experience negative emotions. These negative emotions have included irritability, fear, sadness, anxiety, worry, hostility, alterations in self-awareness, and feelings of vulnerability and uncontrollability.

People with a high level of neuroticism tend to be more likely to experience negative emotions intensely and more frequently compared to those with a low level of neuroticism. They may be more susceptible to stress, anxiety and depression. In addition, they may have a greater emotional reaction to challenges and adverse situations in everyday life.

On the other hand, people with low neuroticism tend to be more emotionally stable, are more resistant to stress, and tend to maintain a calmer and more optimistic attitude even in the face of difficult situations.

It is important to note that neuroticism is not considered intrinsically negative. All personality traits, including neuroticism, exist on a spectrum and may have advantages in certain situations. For example, people with a moderate level of neuroticism may be aware of potential problems and take steps to address them. However, when neuroticism is at extremely high levels, it can interfere with a person`s quality of life and daily functioning.

Neuroticism is influenced by a combination of genetic, biological, environmental and life experience factors. Among the biological factors we can find that differences in the activity of the limbic system and the amygdala, areas of the brain related to emotions, can influence neurotic tendencies. In turn, traumatic events, family difficulties, bullying, cultural values or social norms, among others, may contribute to the development of emotional and cognitive patterns associated with neuroticism.

Number of observed variants

13.5 million variants

Number of risk loci

85 loci

Genes analyzed

CSF3R ZNF648 KLHL29 VRK2 ACVR2A NR4A2 ZNF804A VWC2L PLCL2 ARPP21 BBX PCCB VEPH1 DHX15 TENM3 MEF2C POU5F2 FBXL17 MMS22L SIM1 CENPW MAD1L1 TMEM106B GTF2IRD1 GRM3 FOXP2 CTTNBP2 GRM8 CSMD1 PRAG1 MSRA PRSS51 XKR6 GATA4 DLC1 GLIS3 PTPRD ELAVL2 LINGO2 PHF2 PTCH1 TLR4 SORCS3 EMX2 ARNTL C11orf58 PAX6 MTCH2 ZDHHC5 GRM5 NCAM1 DRD2 KIRREL3 MYO1H SPRING1 FBXO21 TAOK3 PCDH9 KLHL1 STK24 DCAF5 RGS6 YLPM1 SQOR SEMA6D OAZ2 LINGO1 AGBL1 RBFOX1 TMEM114 SETD1A FBXO31 CLUH CRHR1 PRKCA PVALEF CDH2 CELF4 PIK3C3 CCDC68 TCF4 ZNF507 GGT7 TEF

Bibliography

García A.M., Sánchez-Meca J., et al . Neuroticism and suicidal thoughts: a meta-analytic study. Rev. Esp. Salud Publica vol.92 Madrid 2018 Epub 16-Aug-2018

Widiger T.A. et Oltmanns J.R . Neuroticism is a fundamental domain of personality with enormous public health implications. World Psychiatry. 2017 Jun; 16(2): 144-145.

Luciano M., Hagenaars S.P., et al . Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism. Nature Genetics, 18 Dec 2017, 50(1):6-11.

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