Probability of snoring

Snoring is a loud, vibrating noise that occurs during sleep due to a partial blockage in the upper airway. In some cases, snoring may be a sign of a more serious breathing disorder, such as sleep apnea.

Snoring is a loud, raspy, hoarse breathing sound that occurs during sleep. This sound is the result of the vibration of the upper airway structures as air moves in and out as you breathe. Although it is a common experience in most people, sporadically, it can become a chronic problem and, in certain circumstances, may be an indication of more significant health disorders. This phenomenon occurs in the nasopharynx and affects a significant percentage of the population, being more frequent in men (57%) than in women (40%). Moreover, the prevalence increases with age. However, the perception of snoring and its response are subjective, which makes estimates of its prevalence variable.

When snoring is persistent and of high intensity, it can cause sleep difficulties for both the snorer and his or her bed partner, and can sometimes be a sign of sleep apnea. Additional symptoms include daytime anxiety, risk of depression, frequent awakenings, morning headache, nighttime gasping or choking, fatigue, and excessive daytime sleepiness.

The non-genetic risk factors that predispose to the appearance of this trait are the following:

  • Overweight or obesity.
  • Tobacco and alcohol consumption.
  • Advanced age.
  • Abnormal structures that block the flow of air: deviation of the nasal septum, congested nose due to cold or allergies, soft palate, inflammation of the tonsils or nasal polyps.
  • Poor muscle tone.
  • Postmenopausal state.

Addressing this feature involves considering lifestyle changes, such as weight loss, avoiding alcohol and tobacco use, and a preference for sleeping with the head elevated or in lateral decubitus. There are also medical and surgical options available to attenuate snoring, although their necessity and effectiveness vary from individual to individual.

Number of observed variants

13.5 million variants

Number of risk loci

37 loci

Genes analyzed

ANAPC4 AOPEP BCL11B BCL2 BDNF BMP2 CEP120 DHFR2 DLEU7 EPHA3 FAF1 FOXO1 GATA3 HIC1 KCNJ16 KHDC1L LINC02210-CRHR1 LMO4 MACF1 MSRB3 NOG NR4A2 PEX2 PITX1 POC5 PRIM1 PRSS35 PTBP2 ROBO2 RPGRIP1L SIM1 SND1 SNX11 STX4 TFAP2C TNFSF12 TRAM1 TSHZ3 TYR

Bibliography

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