Reactive oxygen species (ROS), such as hydrogen peroxide, are constantly generated in our body from cell metabolism and multiple exposure processes causing DNA lessions that may lead to malignant transformation.
Antioxidant mechanisms protect cells against oxidative damage induced by ROS. The first line of defence against ROS are the antioxidant enzymes manganese superoxide dismutase (SOD2), glutathione peroxidase 1 (GPX1) and catalase (CAT), which detoxify the superoxide anion and hydrogen peroxide. Their activity and ability to protect cells and tissues from ROS and their damaging products are influenced by functional genetic polymorphisms in antioxidant genes.
Gene or region studied