Glucose is the main sugar found in the blood. It is the main source of energy for all cells and its blood levels are finely regulated. Its alteration can lead to pathologies such as diabetes.
Blood glucose
Glucose is a monosaccharide, a form of sugar. It is the most abundant organic compound in nature and is the primary source of energy for cells.
In general, sugars ingested with food are converted to glucose in metabolic processes. Glucose reaches the bloodstream to reach all tissues of the body.
Blood glucose levels vary throughout the day, between 70 and 145 milligrams per deciliter of blood, being lower on an empty stomach and rising after food intake (postprandial glycemia).
Increased glucose, measured on an empty stomach, is related to the onset of diabetes. In these cases, insulin, which is the hormone responsible for lowering blood glucose after meals, does not work properly and it accumulates in the blood. In the initial stages of alteration (also known as pre-diabetic state), changes in lifestyle habits are usually sufficient to control it.
However, sometimes high blood glucose levels maintained over time can lead to the development of diabetes. Diabetes is a chronic disease in which either there is not enough insulin, or the cells do not respond to it adequately, leaving too much sugar in the bloodstream, which over time and with poor control can cause serious health problems such as heart disease, hearing loss (which can in turn lead to social problems and anxiety), vision loss and kidney disease.
Although blood glucose levels are especially linked to lifestyle, genetic factors have been identified that can cause these levels to vary within the physiological range.
13.5 million variants
69 loci
Bibliography
Chen J, Spracklen CN, Marenne G, et al. The trans-ancestral genomic architecture of glycemic traits. Nature Genetics. 2021 Jun;53(6):840-860
Centers for Disease Control and Prevention (CDC) [April 2022].
NIH: National Institute of Diabetes and Digestive and Kidney Diseases [July 2021]