Variants affecting genes involved in the activation of the cells responsible for muscle regeneration are relevant to understanding why some people require more time to recover after a muscle injury.
Exercise-induced muscle damage (regeneration capacity)
Muscle damage involves a series of alterations that occur in three main phases: a first phase, in which mechanical damage occurs. The second phase, which is a consequence of the first, in which inflammation occurs and finally the regeneration phase after muscle damage.
The third phase of muscle regeneration involves the active participation of satellite cells. These cells are the stem cells of the muscle and are found around the muscle cells (known as muscle fibers). The satellite cells are activated by substances produced during the previous inflammatory stage and participate in the regeneration of damaged fibers, or replace dead fibers allowing muscle recovery after injury.
Genes analyzed
SLC30A8
SOD2
Bibliography
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