Intraocular pressure (IOP) is the measure of the fluid pressure inside the eye and plays an essential role in maintaining the shape and function of the eyeball. Variations in IOP are linked to eye diseases such as glaucoma, retinal detachment and uveitis.
Intraocular pressure
Ocular pressure, known as intraocular pressure, refers to the pressure of the fluid inside the eye. The eye contains two fluids, the vitreous humor in the posterior chamber and the aqueous humor in the anterior chamber. IOP is primarily determined by the balance between the production and drainage of aqueous humor.
The standard IOP measurement is in millimeters of mercury (mmHg), and normal values are between 10 and 20 mmHg. Having abnormally high or low eye pressure can be detrimental to vision. Ocular hypertension is the elevation of IOP without additional symptoms, and may cause no harm in some individuals, while others may suffer vision loss even with apparently normal IOP. Glaucoma, on the other hand, is a disease in which chronic high IOP can damage the optic nerve and cause permanent vision loss, if not properly treated. Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. For this reason, it is vitally important to control and reduce IOP, as it plays a key role in preventing and slowing the progression of this eye disease.
Non-genetic factors that have been linked to intraocular pressure (IOP) include the presence of type 2 diabetes, systolic blood pressure (both hyper- and hypotension), body mass index, extreme myopia, age, history of eye disease and a history of myopia.a, age, family history of glaucoma or ocular hypertension, ethnicity (where Africans and Hispanics are at higher risk), prolonged steroid use, and history of previous eye injury or surgery.
To prevent ocular hypertension and maintain good overall eye health, it is important to schedule regular eye exams, avoid smoking and use protective measures such as sunglasses. In addition, a healthy diet with green leafy vegetables and fish rich in omega-3 fatty acids, along with regular exercise and control of blood pressure, cholesterol and blood sugar levels, are key measures to maintain good eye health.
Number of observed variants
13.5 million variants
Number of risk loci
158 loci
Genes analyzed
Bibliography
Gao XR, Huang H, Nannini DR, et al . Genome-wide association analyses identify new loci influencing intraocular pressure. Hum Mol Genet. 2018 Jun 15;27(12):2205-2213.
Machiele R, Motlagh M, Patel BC. Intraocular Pressure. StatPearls. 2022, July.