Intraocular pressure

Intraocular pressure (IOP) is the measure of the fluid pressure inside the eye and plays an essential role in maintaining the shape and function of the eyeball. Variations in IOP are linked to eye diseases such as glaucoma, retinal detachment and uveitis.

Ocular pressure, known as intraocular pressure, refers to the pressure of the fluid inside the eye. The eye contains two fluids, the vitreous humor in the posterior chamber and the aqueous humor in the anterior chamber. IOP is primarily determined by the balance between the production and drainage of aqueous humor.

The standard IOP measurement is in millimeters of mercury (mmHg), and normal values are between 10 and 20 mmHg. Having abnormally high or low eye pressure can be detrimental to vision. Ocular hypertension is the elevation of IOP without additional symptoms, and may cause no harm in some individuals, while others may suffer vision loss even with apparently normal IOP. Glaucoma, on the other hand, is a disease in which chronic high IOP can damage the optic nerve and cause permanent vision loss, if not properly treated. Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma. For this reason, it is vitally important to control and reduce IOP, as it plays a key role in preventing and slowing the progression of this eye disease.

Non-genetic factors that have been linked to intraocular pressure (IOP) include the presence of type 2 diabetes, systolic blood pressure (both hyper- and hypotension), body mass index, extreme myopia, age, history of eye disease and a history of myopia.a, age, family history of glaucoma or ocular hypertension, ethnicity (where Africans and Hispanics are at higher risk), prolonged steroid use, and history of previous eye injury or surgery.

To prevent ocular hypertension and maintain good overall eye health, it is important to schedule regular eye exams, avoid smoking and use protective measures such as sunglasses. In addition, a healthy diet with green leafy vegetables and fish rich in omega-3 fatty acids, along with regular exercise and control of blood pressure, cholesterol and blood sugar levels, are key measures to maintain good eye health.

Number of observed variants

13.5 million variants

Number of risk loci

158 loci

Genes analyzed

MFAP2 COL16A1 COL8A2 DNALI1 COL24A1 GTF2B MOV10 UCK2 NTMT2 PRRX1 TGFB2 LYPLAL1 ZC3H11B SOX11 FOSL2 TRMT61B LTBP1 FEZ2 ZFP36L2 SIX3 SPTBN1 EFEMP1 MEIS1 ANTXR1 REV1 RALB FMNL2 TNS1 MFF ASB1 SEMA3F CADM2 ALCAM UMPS STAG1 MECOM GHSR DGKG LPP AFAP1 C4orf36 STOX2 AHRR SLC1A3 ADAMTS6 MRPS27 THBS4 FER CDO1 LOX SLC27A6 ADAMTS19 PDLIM4 HUS1B FOXC1 GMDS FKBPL PKHD1 TRAM2 IBTK LIN28B TRAF3IP2 CENPW MTFR2 SYNJ2 SEMA3C COL26A1 CAV1 CTTNBP2 ANGPT2 C8orf48 PKIA TP53INP1 ANGPT1 FBXO32 GLIS3 MPDZ MAMDC2 ABCA1 LMX1B ABO COL5A1 PTGDS PRTFDC1 GPR158 JCAD TMEM26 ARID5B ANKRD1 MYOF KAZALD1 NEURL1 TCF7L2 CEND1 PLEKHA7 METTL15 C11orf49 PSMC3 PTPRJ OR4A47 TRIM51GP OR4C13 OR4C12 TRIM48 OR5AP2 ME3 TYR ARHGAP20 GRIK4 ETS1 ADAMTS8 LUM IGF1 GLT8D2 TMEM119 ZNF891 FOXO1 WBP4 LMO7 NDFIP2 NPAS3 TTC6 FERMT2 DPF3 PRTG VPS13C IQCH ODF3L1 AKAP13 MESP2 ADAMTS17 MAPK8IP3 ADAMTS18 ZNF469 VPS9D1 HIC1 CAMTA2 GAS7 ALDH3A1 PIP4K2B WNT9B PHOSPHO1 BCAS3 OTOP3 SEPTIN9 NPLOC4 TCF4 ZNF516 SPC24 CPXM1 JAG1 MAFB PTPN1 ETS2 TANGO2 RIMBP3C EMID1 TIMP3 H1-0

Bibliography

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