Systolic blood pressure levels

Systolic blood pressure is the pressure exerted by the blood ejected by ventricular systole against the arterial wall. The study of blood pressure levels is of utmost importance, especially when an increase is detected, as this constitutes a significant risk factor for the development of cardiovascular diseases.

Blood pressure is a measure that represents the force that blood exerts on the walls of the arteries. This measurement is presented in two figures: systolic blood pressure (SBP), which reflects the force exerted when blood is ejected from the heart, and diastolic blood pressure (DBP), which corresponds to the pressure exerted between beats when the heart is at rest.

Regular assessment of systolic and diastolic blood pressure is essential for the control of your cardiovascular health, as it allows you to detect and prevent possible cardiac and vascular problems. The normal SBP value is below 120 mmHg.

In the case of having an SBP value equal to or less than 90 mmHg we are in a situation of low blood pressure or hypotension. In this case, the individual may not experience any obvious symptoms, or may experience dizziness, blurred vision, fainting, fatigue, nausea or difficulty concentrating.

If the systolic blood pressure (SBP) value is equal to or greater than 130 mmHg, it is considered high blood pressure or hypertension. In most cases, this condition does not manifest itself with clear symptoms, although very high blood pressure can cause symptoms similar to those of hypotension, such as dizziness, nausea, vomiting, severe headache, chest pain, confusion, anxiety and blurred vision. Hypertension is a significant risk factor for cardiovascular disease, including heart disease, stroke, and kidney failure.

Risk factors that modify systolic and diastolic blood pressure levels include:

  • Advanced age.
  • Family history.
  • Physical inactivity.
  • Alcohol and tobacco consumption.
  • Diets rich in salt, saturated and trans fats.
  • Antidepressants, hormonal contraceptive pills and non-steroidal anti-inflammatory drugs (NSAIDs) can increase blood pressure, while diuretics, drugs to treat erectile dysfunction (Viagra) and other drugs can increase blood pressure.drugs to treat erectile dysfunction (viagra), some antidepressants (doxepin) and alpha- and beta-blockers lower blood pressure.
  • Ethnicity. African-American adults tend to have higher blood pressure values than the world population average.

Healthy lifestyle habits, such as following a balanced diet rich in fruits and vegetables, maintaining regular physical activity and moderating alcohol and tobacco consumption, are tools that can help maintain blood pressure within healthy values, and thus reduce the risk of developing associated pathologies.

Number of observed variants

13.5 million variants

Number of risk loci

125 loci

Genes analyzed

AKAP11 APOLD1 APPL2 AQP1 ARHGAP29 ARHGEF25 ARL14EP ATP2B1 BAHCC1 BCAS3 BCL11A BCL2 BMPR1B BNIP3 BOD1L2 C11orf24 CAPRIN1 CCT6A CDKAL1 CEP85L CITED2 CKAP5 CNTN3 COPRS COX8A CRB1 CTNNB1 DNER EDEM3 ENO4 EPB41L2 ERAP1 ERBB4 FGF9 FNBP1L FOXC1 GABRA2 GDF2 GLIS3 GSE1 HINT3 HNMT IER5L IGF1 INPP5A IRF6 JAZF1 KDM4B KIAA1614 KLF14 KLF5 KLHL25 LCORL LRCH1 LTBP2 MAP3K1 MARK3 MEF2A MEIS1 MEX3C MIEF2 MKRN1 MLF1 MSRA MYBPH MYC NFATC2 NIBAN2 NRG4 NRXN1 NT5C1B OMD OR4C46 PAWR PBX3 PCCB PCDH18 PDE8A PDGFC PHTF2 PLA2G12B PLPP5 PLXNB2 POM121C PPM1E PRKD1 PRSS55 PTPRD RAD52 RARRES2 RBFOX1 RBM26 RBMS1 RGS6 RNASEH2B RPL27A RTN4 RXFP2 SEMA4A SKI SLC12A2 SLC30A5 SOX5 SREK1 SZT2 TARS1 TASOR2 TERT TFCP2L1 TGFBR2 THADA TMEM108 TMEM87B TNIP2 TOX TSNARE1 USP4 WNT4 YES1 ZBTB10 ZBTB20 ZMAT2 ZNF692 ZNF804A ZSWIM2

Bibliography

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