Clobazam (Adverse Reactions)

Clobazam is a long-acting benzodiazepine used as an anxiolytic and in combination with other medications to treat seizures caused by epilepsy.

Its mechanism of action consists of increasing GABA activity by facilitating its binding to the GABAergic receptor.

CONTRAINDICATIONS

Hypersensitivity to clobazam and benzodiazepines.

Myasthenia gravis, sleep apnea syndrome, severe respiratory insufficiency, severe hepatic insufficiency, narrow-angle glaucoma.

Do not ingest during lactation.

PRECAUTIONS

Do not administer to children under 3 years of age, except in exceptional cases where treatment is essential, nor to the elderly. Psychiatric and paradoxical reactions are more frequent in children and the elderly.

Ingestion of clobazam can cause hepatic insufficiency, renal insufficiency, and chronic or acute respiratory insufficiency.

Individuals who are poor metabolizers of clobazam (see technical report) may require dose adjustment.

In patients suffering from pre-existing muscle weakness or spinal or cerebellar ataxia, special monitoring and a reduction in the drug's dosage should be carried out.

After continued use of the drug, there is a risk of tolerance and physical-psychic dependence. Abrupt discontinuation after continued use causes withdrawal syndrome. Do not use in anxiety associated with depression or as a primary treatment for psychotic illness.

SIDE EFFECTS

Somnolence, affective blunting, reduced alertness, confusion, fatigue, headache, dizziness, vertigo, muscle hypotonia, muscle weakness, ataxia, diplopia, amnesia, depression, psychiatric and paradoxical reactions, dry mouth, constipation, decreased appetite, nausea, weight gain, and dependence.

TRADE NAMES

• Noiafen ®
• Onfi ®