Docetaxel (Adverse effects)

Docetaxel is an antimitotic drug used in therapy against some types of cancer. The presence of certain polymorphisms may increase the risk of developing leukopenia/neutropenia as a serious adverse effect.

Docetaxel is an antineoplastic taxoid chemotherapy drug with less toxicity than other antineoplastic drugs of the taxoid family. It works by stopping the growth and spread of cancer cells.

Docetaxel is used to treat locally advanced or metastatic breast cancer, especially metastatic HER2+ breast cancer as first-line therapy together with Trastuzumab.

It is used in metastatic non-small cell or locally advanced lung cancer and metastatic hormone-refractory prostate together with prednisone.

Docetaxel is also considered a first-line treatment of metastatic gastric adenocarcinoma and an induction treatment in patients with locally advanced squamous carcinoma of the head and neck. Summarizing, in cancers that have already metastasized.


BRAND NAMES

  • Docetaxel®


Genes analyzed

SLCO1B3

Bibliography

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