Actinic keratosis

Actinic keratoses are precancerous skin lesions that can appear after the age of 40 years and have a scaly appearance, caused by frequent or intense exposure to ultraviolet (UV) rays from the sun or from artificial sources, such as tanning beds.

  • Prolonged exposure to UV rays (both recreational and occupational).
  • Having a history of intense sun exposure or sunburn increases the risk.
  • Having a pale skin phototype and a tendency to freckle or burn with sun exposure increases the risk.
  • The prevalence of actinic keratosis is higher in men than in women.
  • People with compromised immune systems, such as those who have received organ transplants, are more susceptible.
  • The presence of other pathologies such as diabetes, rheumatoid arthritis and psoriasis may influence the development of actinic keratosis.

Symptoms

Actinic keratosis is most common in regions of skin chronically exposed to the sun. Lesions appear as thin or raised papules with a reddish-brown or yellowish-black color or appear as plaques with an appearance of dry adherent scales. The lesions may be asymptomatic or cause itching, burning or tenderness. Occasionally they may bleed or crust over.

Actinic keratosis may progress to squamous cell carcinoma in approximately 10% of cases, so these patients should be followed regularly.

Prevention

Sun protection helps prevent actinic keratosis. The following measures are recommended to protect the skin from the sun:

  • Use broad-spectrum sunscreen with a sun protection factor (SPF) of at least 30 and apply it before sun exposure and regularly, every two hours or so, while you are exposed. Use sunscreen also on cloudy days.
  • Wear protective clothing and a wide-brimmed hat that provides greater protection than hats and visors.
  • Reduce the amount of sun exposure time and avoid exposure between 10:00 am and 2:00 pm.
  • Avoid sunbeds and other sources of artificial UV light.
  • Inform your doctor if you notice new growths or changes in existing moles, freckles, bumps and birthmarks.

Number of observed variants

13.5 million variants

Number of loci analyzed

11 loci

Genes analyzed

ANKRD33B BNC2 EIF2S2 IRF4 KRT85 N4BP2L1 OCA2 PIK3C2B SLC45A2 TUBB3 TYR

Bibliography

FinnGen. FinnGen Documentation of R6 [2022/01].

Hensen P, Müller ML, Haschemi R, et al. Predisposing factors of actinic keratosis in a North-West German population. Eur J Dermatol. 2009 Jul-Aug;19(4):345-54.

Lee YB, Kim JI. Genetic Studies of Actinic Keratosis Development: Where Are We Now? Ann Dermatol. 2023 Dec;35(6):389-399.

Martincorena I, Roshan A, Gerstung M, et al. Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science. 2015 May 22;348(6237):880-6.

What do your genes say about you? Start your journey today.

Get a special 5% discount on your first kit.

Haven't you taken our DNA test yet?

Get your genetic test and discover what your DNA says about you.

pack
Starter DNA test
The best option to get started

Ancestry service, Traits and Wellness

Buy
pack
DNA test Advanced DNA test
Know your DNA in depth

Health, Ancestry service, Traits and Wellness

Buy
pack
Genetic analysisUltra
Whole Genome Sequencing 30x

Health, Ancestrality, Traits and Wellness

includes three months of tellmeGen+

Buy

Important information and limitations

Europe
Austria
Belgium
Czech Republic
Denmark
Finland
Germany
Hungary
Ireland
Italy
Netherlands
Norway
Poland
Portugal
Romania
Spain
Sweden
Switzerland
United Kingdom
Asia
Kazakhstan
Saudi Arabia
UAE
America
Brazil
Canada
Chile
Colombia
Mexico
Panama
Peru
United States
Oceania
Australia
Halloween Promotion Only until November 1st Use our coupon HALLOWEEN10
Buy