Anxiety

Anxiety and fear are normal responses to potential or actual threats that when excessive, prolonged and occurring at inappropriate times lead to pathological anxiety that interferes with the person's normal activity. Genetic factors are believed to play an important role in the development of anxiety disorders, in addition to other factors.

Anxiety disorders are common psychiatric conditions, which may affect at some point one third of the adult population and have a moderate heritability of 30-40%. In addition to genetics, other factors may play a role:

  • Anxiety disorders are more frequent in women than in men.
  • Chronic psychosocial stress at various stages of life.
  • Acute traumatic events.
  • Presence of other illnesses such as diabetes, thyroid problems, heart problems, respiratory disorders etc.
  • Inappropriate use of substances and abstinence from alcohol and medications such as benzodiazepines.

Symptoms

  • Feeling of nervousness
  • Increased heart rate and hyperventilation
  • Sweating, dizziness, tremors
  • Muscle tension, pain or feeling of pressure in the chest
  • Feeling of weakness or tiredness
  • Problems concentrating and excessive worrying
  • Sleep problems
  • Gastrointestinal disturbances
  • Behavioral disturbances, such as a tendency to avoid certain situations

Prevention

  • Engage in regular physical activity
  • Avoiding smoking, alcohol and illicit drug use
  • Stress reduction techniques
  • Psychotherapy

Number of observed variants

13.5 million variants

Number of loci analyzed

39 loci

Genes analyzed

AGBL1 AGER APOM CLUH CSF3R DENND1B DRD2 FBXO21 FBXO31 FCF1 GRM8 H2BC13 HLA-B HSPA5 KLHL1 L3MBTL2 MAT2B MC4R MMS22L NCAM1 NR4A2 OTX1 PCDH17 PHF2 PIK3C3 PLCL2 PTCH1 PTPRD RPP21 SFMBT1 SIM1 SNCA TBL1XR1 TMEM114 TMEM161B TSNARE1 VRK2 ZDHHC5

Bibliography

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