Non-celiac intestinal malabsorption

Intestinal malabsorption results in insufficient absorption of sugars, fats, proteins and vitamins from food. It is generally associated with intestinal damage caused by multiple pathologies or other factors.

Intestinal malabsorption can be caused by a large number of pathologies such as celiac disease, Crohn's disease, chronic liver disease, pernicious anemia, chronic pancreatitis, cholestasis, cystic fibrosis, etc.

Intestinal malabsorption can also be caused by infections (bacteria, viruses and protozoa), surgical interventions (such as gastric bypass and gastrectomy), intolerances (lactose intolerance), food allergies, certain drugs and alcohol consumption.

Symptoms

In children it may cause retarded growth and development. In adults, it may cause loss of weight and muscle mass, weakness and cognitive problems. There are also frequent digestive alterations such as:

  • Abdominal distention
  • Colic
  • Gas
  • Chronic diarrhea (not present in all cases)
  • Greasy stools (steatorrhea)

Prevention

There are no specific recommendations to prevent intestinal malabsorption and treatment will vary depending on the patient's possible pathologies that may be associated with intestinal malabsorption.

Number of observed variants

13.5 million variants

Number of loci analyzed

14 loci

Genes analyzed

BAK1 BTN1A1 CCR3 H4C8 IL12A IL21 IP6K3 LPP MLN OLIG3 SH2B3 ZBTB9 ZSCAN12

Bibliography

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