Urolithiasis

Urolithiasis is the accumulation of stones or "calculi" in the urinary tract (kidneys, ureters, and bladder) that are formed by the crystallization of minerals or acidic salts. It can present with pain and cause obstruction, bleeding, or infection. It is a common condition, affecting about 1 in 10 people.

Kidney stones usually form in concentrated urine or due to excess substances that can promote their appearance, such as calcium, oxalate, or uric acid, but the predisposing factors can be multiple. Among them, the following are included:

  • It is more common in men than in women.
  • Family or personal history. Having an affected family member or having had a previous episode can increase the risk.
  • Low water intake. Not drinking enough water or living in hot and dry climates that increase sweating can lead to more concentrated urine and a higher risk.
  • Consumption of foods rich in protein, salt, and sugar.
  • Obesity.
  • Digestive diseases, such as inflammatory bowel disease or chronic diarrhea, can affect water absorption, increasing the risk.
  • Consumption of certain supplements and medications, such as vitamin C, laxatives, or certain medications used to treat depression and migraine.

Symptoms

It is most common for the presence of kidney stones to be associated with colicky pain that occurs when the stone obstructs the normal flow of urine. It is a sharp pain located in the lower back but can radiate to the groin and, in the case of men, even affect the testicle on the same side. Other signs and symptoms that may appear include the presence of blood in the urine.

Sometimes the pain is mild or even painless, depending on the type, size, shape, and location of the stone.

Prevention

The presence of stones in the urinary tract is one of the most common urological conditions. Prevention involves avoiding risk factors, with recommendations such as the following:

  • Drink plenty of water throughout the day and reduce salt intake.
  • Moderate consumption of animal protein.
  • Avoid foods high in oxalate, especially for individuals prone to accumulating this compound. These foods include coffee, cocoa, spinach, strawberries, tea, nuts, and wheat, among others.
  • Taking medications that may be useful for those prone to developing stones, which can vary depending on their composition, so it is important to consult a doctor.

Number of observed variants

13.5 million variants

Number of risk loci

30 loci

Genes analyzed

ABCG2 AKAP11 ALPL AQP1 BCAS1 CASR CHAF1B DGKD DZIP1 EPB41L2 GCKR GNAZ HCRTR2 HIBADH KCNK5 MIPOL1 MYOCD NUTM2A PDILT PTGER1 SHROOM3 SLC22A2 SLC30A10 SLC34A1 SOX9 TBX2 TFAP2B UGT8 WDR72 ZFP36L2 ZFPM1

Bibliography

What do your genes say about you? Start your journey today.

Get a special 5% discount on your first kit.

Haven't you taken our DNA test yet?

Get your genetic test and discover what your DNA says about you.

pack
Starter DNA test
The best option to get started

Ancestry service, Traits and Wellness

Buy
pack
DNA test Advanced DNA test
Know your DNA in depth

Health, Ancestry service, Traits and Wellness

Buy
pack
Genetic analysisUltra
Whole Genome Sequencing 30x

Health, Ancestrality, Traits and Wellness

includes three months of tellmeGen+

Buy

Important information and limitations

Europe
Austria
Belgium
Czech Republic
Denmark
Finland
Germany
Hungary
Ireland
Italy
Netherlands
Norway
Poland
Portugal
Romania
Spain
Sweden
Switzerland
United Kingdom
Asia
Kazakhstan
Saudi Arabia
UAE
America
Brazil
Canada
Chile
Colombia
Mexico
Panama
Peru
United States
Oceania
Australia
The Best Prices of the Year! Only until November 27 Use our coupon BLACK15
Buy