Corneal curvature

The cornea is fundamental for vision, since its curvature directly influences light refraction and, therefore, visual quality. Alterations in this curvature can result in refractive errors such as myopia and hyperopia. Refractive errors are widespread in the world and one of the most affected populations is the Asian population.

Corneal curvature refers to the shape and curvature of the cornea, the transparent, convex layer that covers the front of the eye and plays a crucial role in the refraction of light. It is a key aspect of the eye's vision, as the surface of the cornea provides approximately two-thirds of the eye's optical power. Changes in the curvature of the cornea can significantly affect refractive error, as occurs in myopia, where a steeper curvature is associated with a more negative or myopic refractive error. In an emmetropic eye (without vision problems), the refractive power of the optical components of the eye, including the curvature of the cornea, must be properly aligned with the axial length of the eye to avoid refractive errors such as myopia or hyperopia.

Problems in the refractive ability of the eye are a common error worldwide, particularly in Asia, where uncorrected refractive error is a major cause of visual impairment and blindness.

Measurement of corneal curvature can be performed by different specialized methods, although corneal topography is one of the most commonly used. This technique uses Placido rings or laser scanning systems to generate a detailed three-dimensional map of the corneal surface. The average curves of an emmetropic eye are between 42 and 45D.

Number of observed variants

13.5 million variants

Number of risk loci

39 loci

Genes analyzed

ADAMTS20 ADAMTS3 ADAMTS7 BMP7 CHRND COL5A1 COL6A1 CWC27 EXOSC10 FBN1 FGF9 FRAT1 GHSR HDAC11 HMGA2 IGFBP5 INS-IGF2 INTS6 INTU KAZALD1 LCORL LMX1B MAPRE2 MARCKS MINAR2 NHSL1 PDGFRA PKIA PRL RNLS RSPO1 SOX2 STON2 STXBP6 TFAP2A THBS4 TNS3 USP1

Bibliography

Fan Q, Pozarickij A, Tan NYQ, et al. Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error. Commun Biol. 2020 Mar 19;3(1):133.

Guggenheim JA, McMahon G, Kemp JP, et al. A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans. Mol Vis. 2013;19:243-53. Epub 2013 Jan 3.

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