The neutrophil count is a crucial indicator of immune health and the body's ability to fight infection. This count depends on a variety of factors, including age, gender, health status, and medication.
Neutrophil count
Neutrophil count is a crucial measure in assessing an individual's immune health. Neutrophils are a type of white blood cell and form the body's first line of defense against bacterial and fungal infections. Their primary role is to phagocytize and destroy pathogens, releasing enzymes and antimicrobial compounds that help control and eliminate infections. An adequate neutrophil count is essential to maintain the body's ability to respond to infections and prevent disease. A low count, known as neutropenia, may predispose to recurrent and serious infections, while an elevated count, known as neutrophilia, may indicate an acute inflammatory or infectious response, or be a sign of conditions such as leukemia.
Several factors can influence a person's neutrophil count. Among physiological factors, age and gender play an important role; neutrophil counts can vary between different age groups and between men and women. Infections and inflammatory responses are also determining factors; during an acute or chronic infection, the body produces more neutrophils to fight pathogens. Underlying medical conditions, such as autoimmune disorders, cancer and bone marrow diseases, can also affect neutrophil counts. In addition, certain medications, especially chemotherapeutics and immunosuppressants, can lower neutrophil counts, while corticosteroids can increase neutrophil counts.
Number of observed variants
13.5 million variants
Number of risk loci
636 loci
Genes analyzed
Bibliography
Vuckovic D., Bao E.L., et al. The Polygenic and Monogenic Basis of Blood Traits and Diseases. Cell, 01 Sep 2020, 182(5):1214-1231.e11.
Skokowa J., Dale D.C., et al. Severe congenital neutropenias. Nat Rev Dis Primers. 2017 Jun 8; 3: 17032.
