Bone mineral density (BMD) refers to the amount of minerals, mainly calcium and phosphorus, present in the bones. An adequate BMD level is essential to maintain strong and resistant bones.
Bone mineral density
Bone mineral density is a critical factor for the health of bones and the musculoskeletal system in general. Throughout life, bone is a dynamic tissue that undergoes a constant process of resorption and formation. During childhood and adolescence, bone mass undergoes a significant increase, reaching its peak in approximately the third decade of life. This period of bone mass accumulation is essential for establishing a solid foundation of bone density that contributes to lifelong bone strength.
However, as we age, especially after the age of 50 and particularly in women after menopause, the balance between bone formation and bone resorption tends to become unbalanced. Bone resorption, which is the loss of bone tissue, exceeds the rate of bone formation, resulting in a decrease in BMD. This situation results in marked bone fragility, increasing susceptibility to fractures, which represents a significant health problem and raises the risk of developing diseases such as osteoporosis.
There are several non-genetic risk factors that can negatively influence bone mineral density. These factors include smoking, alcohol consumption, a sedentary lifestyle, gender, a diet deficient in vitamins and calcium, aging, the use of certain medications such as corticosteroids, as well as medical conditions such as arthritis and osteoporosis.In addition to medical conditions such as rheumatoid arthritis, chronic kidney disease, hyperparathyroidism, chronic liver disease or celiac disease.
To prevent altered bone mineral density levels and reduce the risk of bone diseases such as osteoporosis, it is essential to maintain a healthy lifestyle. This involves avoiding tobacco and alcohol consumption, as well as giving priority to a diet that is rich in calcium and vitamin D.
Number of observed variants
13.5 million variants
Number of risk loci
76 loci
Genes analyzed
Bibliography
Medina-Gomez C, Kemp JP, Trajanoska K, et al. Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. Am J Hum Genet. 2018 Jan 4;102(1):88-102.
Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017 Mar;4(1):46-56.