Urate levels

Urate levels are an important marker of health that is influenced by a combination of dietary, metabolic, renal and genetic factors. Maintaining adequate urate levels is crucial to prevent painful and debilitating conditions such as gout and reduce the risk of cardiovascular and kidney disease.

Urate is an end product of the metabolism of purines, which are building blocks of DNA and RNA. Blood urate levels, also known as uric acid levels, are an important indicator of several health conditions. Urate balance is essential for normal body function, but abnormally high levels can lead to the formation of urate crystals, which deposit in joints and tissues, causing inflammation and pain, characteristic of gout. In addition, elevated urate levels are associated with other conditions such as hypertension, chronic kidney disease and cardiovascular disease. On the other hand, low levels of urate may be related to neurodegenerative diseases due to urate's antioxidant role.

Urate levels in the body depend on several factors, including diet, metabolism, kidney function and hydration status. Eating foods rich in purines, such as red meat, seafood and certain types of alcohol, can increase urate levels. In addition, the body's ability to metabolize and excrete urate, primarily through the kidneys, is crucial. Kidney dysfunction can lead to inadequate urate elimination, resulting in its accumulation in the body. Other factors include the use of certain medications, excessive alcohol consumption and obesity, which can contribute to elevated urate levels. Adequate hydration and a balanced diet are essential for maintaining healthy urate levels.

Number of observed variants

13.5 million variants

Number of risk loci

241 loci

Genes analyzed

A1CF AAK1 ABCA1 ABCG2 ACVR2A ORC4 ADGRL2 ADGRV1 AKAP13 AMPD2 ANKRD28 ANKRD55 AP4E1 APH1B ARHGEF26 ARID1A ARL15 ATP1B3 ATP5PO ATXN2 B4GALT1 BCL2L11 BIRC6 BMP5 BMPR2 C12orf43 C2orf74 C4orf36 CASTOR1 CCDC17 CCNL1 CEMIP CLDN10 CLDN14 CLDN8 CLNK CNTN2 COQ8A CPEB4 CPS1 CUBN CYB5D1 DACH1 DDHD2 DDX1 DHFR2 DMRTA2 DNAH3 DNAJC13 DNAJC16 DPF3 DR1 EIF5A2 EMX2 EPB41L3 ERBB4 ESRP2 EVX2 FADS1 FAIM2 FAM102A FAM53B FBRSL1 FIGNL2 FMN1 FOXK1 FRK FST FTO FUT8 GBA3 GCKR GLI2 GLIS3 GMDS GNAS GRB2 GSDMC HDAC5 HERC3 HERC4 HLA-F HLF HMGB1 HNF4A HNF4G HNRNPA1L3 HS6ST3 IDH2 IGF1R IGF2 IGFBP3 INHBE INPP5A INS INSR IPO9 IRF2BP2 IRS1 ISLR JAG1 JUND KCNK5 KCTD1 AQP4 KDM4B KLB KLF10 KLF15 LCT LMAN2 LMTK2 LPGAT1 LRP2 LY86 MAF MARK3 MC4R MECOM MED4 MIP MIPOL1 MKRN2OS MLLT3 MLXIP MOK MPPED2 NCKAP5 NCOA7 NDUFAF6 NECTIN2 NFAT5 NR2E3 NRG1 NRG4 NRIP1 NRXN1 NTN4 OGFOD1 PDE1A PDLIM4 PDZK1 PHGDH PIGU PIP5K1B PKD2 PLA2G4A PNPLA3 PPARG PRKAG2 PRXL2A PTGER4 PYGB PYGM QRICH2 QSOX2 RAB11FIP2 RAD17 RAI14 RDH14 RERG RGS5 RNF186 RNF32 RPEL1 RPL31 RRAGD RREB1 RSKR SBF2 SEC61B SENP2 SFMBT1 SH2D6 SHH SHLD2 SKI SLC14A1 SLC14A2 SLC16A10 SLC16A9 SLC17A1 SLC22A11 SLC22A3 SLC39A8 SLC47A1 SLC5A1 SLC5A9 SLC7A9 SLCO1B1 SMU1 SNX32 SPI1 STC1 STK25 SYT1 TBL2 TBX2 TCF21 TFAP2B TFCP2L1 TMEM11 TMEM171 TMEM18 TMEM63B TMF1 TNF TPCN2 TPM2 TRAIP TRAP1 TRIM29 TRIM46 TSPAN33 TTLL10 U2SURP UMOD UNCX USP2 USP38 UVRAG VEGFA WDR1 ZBTB20 ZNF184 ZNF281 ZNF512B ZNF816 ZNF827

Bibliography

Gill D., Cameron A.C., et al. Urate, Blood Pressure, and cardiovascular disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials. Hypertension (Dallas, Tex. : 1979), 28 Dec 2020, 77(2):383-392.

Yu-Lin Ko. Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies. Tzu Chi Med J. 2022 Jul-Sep; 34(3): 261-269.

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