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Lansoprazole Metabolization

Lansoprazole is an antibiotic belonging to the family of so-called PPIs ("proton pump inhibitors") that is used in gastric infections such as those caused by the bacterium Helicobacter pylory.

Its mechanism of action is to inhibit the secretion of acid in the stomach by binding to the proton pump in the gastric parietal cell, inhibiting the transport of H + to the gastric lumen.

When lansoprazole is prescribed, extreme caution should be exercised if there is suspicion that the patient may present malignant gastric tumors and it is recommended to exclude this medication in the event of such tumors.

Ingestion of lansoprazole has certain side effects such as headache, dizziness, nausea, diarrhea, stomach pain, constipation, vomiting, flatulence, dry mouth or throat, increased liver enzymes, urticaria, pruritus, rash, fatigue and benign gastric polyps.

In addition, there exist drug interactions with other medications. Avoid association with ketoconazole and itraconazole.

Lansoprazole reduces plasma concentration of theophylline, caution should be exercised.

Fluvoxamine increased plasma concentration of lansoprazole, dose reduction is recommended. Lansoprazole produces reduced plasma concentration by rifampicin and H. perforatum.

Dosage of antacids and sucralfate is recommended after lansoprazole intake.

BRAND NAMES

  • Estomil ®
  • Lansoprazol ®
  • Lanzol ®
  • Monolitum ®
  • Opiren ®
  • Pro Ulco ®
  • Protoner ®

Symptoms

Trastuzumab injection may provoke side effects: fever and chills related to perfusion (interrupt treatment and continue when it remits), asthenia, headache, insomnia, nausea, vomiting, coughing, dyspnea, rhinitis, sinusitis, hypotension. It can also cause ventricular alteration and congestive heart failure. Rarely, there may be serious side effects such as dyspnea, hypotension, bronchospasm, respiratory distress, hives and angioedema during or within 2.5 hours of beginning the infusion. Used in combination with anthracyclines, it increases the risk of cardiotoxicity.

Gene or region studied

  • CYP2C19
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