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Idiopathic membranous nephropathy

Idiopathic membranous nephropathy is a kidney disorder that leads to changes and inflammation of the structures inside the kidney that help filter wastes and fluids. The inflammation may lead to problems with kidney function.

Membranous nephropathy is caused by the thickening of part of the glomerular basement membrane, a part of the kidneys that helps filter waste and extra fluid from the blood. The thicker glomerular membrane does not work normally and large amounts of protein are lost in the urine as a result. The exact reason for this thickening is not known.

The disorder can appear at any age and is more frequent in men. Generally, it is slow-developing as a cause of nephrotic syndrome (70%) or as a result of asymptomatic proteinuria (loss of large amounts of protein in the urine) (30%).

Idiopathic membranous nephropathy may be a primary kidney disease, or it may be associated with other conditions.


  • HLA-DQA1