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Sjögren syndrome

Sjögren syndrome is a systemic chronic inflammatory disorder of unknown cause identified by its two most common symptoms — dry eyes and a dry mouth due to a decreased function in the lacrimal and salivary glands.

It is a slow progressing disease that can affect up to 3% of the population, the majority of which are middle-aged women, although it can appear at any age.

There are two forms of Sjögren’s syndrome:

  • Secondary Sjögren’s syndrome: it appears simultaneously with rheumatoid arthritis, (RA) or systemic lupus erythematosus (SLE), scleroderma or primary biliary cirrhosis.
  • Primary Sjögren’s syndrome: not associated with another autoimmune illness

External secretion glands are located in the eyes (lacrimal glands), the vagina, the skin, the intestine and in the bronchials. Their progressive destruction causes a reduction of tears and saliva and vaginal, bronchial, intestinal and sweat secretions provoking the sensation of dryness that patients feel. Pain and inflammation of the joints are frequent which is why it is considered a rheumatic disease. In addition, the majority of disease it is associated with are rheumatic diseases.


  • 7q32.1
  • STAT4