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РИСК РАЗВИТИЯ СЛОЖНЫХ ЗАБОЛЕВАНИЙ

Ankylosing spondylitis (AS)

Ankylosing spondylitis (AS) is a chronic inflammatory disease that fundamentally affects the vertebrae in the spine causing it to fuse together and making the spine less flexible. More men (between the ages of 20-30) than women are affected.

Ankylosing spondylitis belongs to the family of spondyloarthropathies (SpA), a heterogeneous group of rheumatic illnesses interrelated in clinical, genetic, radiographic alterations and treatment. Although the exact cause of the disease is unknown, it is known that genetics plays a part in its development and that there is an increased risk for those persons who have a family history of the disease.

GENE OR REGION STUDIED


  • ERAP1
  • LNPEP
  • IL23R
  • IL23R
  • ERAP1
  • IL23R
  • 2p15
  • 1p31.3