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ФАРМАКОЛОГИЧЕСКАЯ СОВМЕСТИМОСТЬ

Sildenafil effect (Viagra ®)

Sildenafil is used to treat erectile dysfunction in men (impotence, inability to have an erection or maintain it). Sildenafil is also used to improve exercise capacity in adults who suffer from pulmonary hypertension.

ACTION MECHANISM

Sildenafil belongs to a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil is used to treat erectile dysfunction because it increases blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Sildenafil also treats pulmonary hypertension by relaxing the blood vessels in the lungs to allow blood to flow easily.

CONTRAINDICATIONS

Sildenafil is contraindicated in individuals with severe hepatic impairment. Caution in mild liver failure: reduce initial dose to 25 mg and, based on tolerance, increase doses to 50 mg and 100 mg.

Caution in individuals with severe renal impairment: initial dose 25 mg and, based on tolerance, increase dose to 50 mg and 100 mg.

CAUTIONS

Caution should be exercised if sildenafil is taken by individuals with severe renal insufficiency, mild hepatic insufficiency, anatomical deformations of the penis (angulation, cavernous fibrosis or Peyronie’s disease) or predisposition to priapism (sickle cell anemia, multiple myeloma or leukemia); hemorrhagic disorders or with active peptic ulcer.

Cardiovascular status should be considered, due to cardiac risk associated with sexual activity.

Sildenafil is not recommended in combination with alpha-blockers, nor with other treatments for erectile dysfunction.

Sildenafil should be discontinued if a sudden visual disturbance occurs.

Sildenafil is not recommended in children and in individuals under 18 years old.

Special caution should be exercised in patients with pulmonary arterial hypertension since there may be an increased risk of bleeding in patients treated with vitamin K antagonist and if treatment is interrupted, gradual dose reduction is recommended.

SIDE EFFECTS

Headache, heartburn, diarrhea, hot flashes (feeling warm), nosebleeds, troubleS to sleep or staying asleep, numbness, burning or tingling in the arms, hands, feet or legs, muscle aches, changes in color vision, rashes.

Other more serious side effects may include: Prolonged erection (priapism) that causes severe pain, sudden loss of vision in one or both eyes, sudden loss of hearing, shortness of breath and difficulty breathing.

BRAND NAMES

  • Viagra®
  • Revatio®

GENE OR REGION STUDIED


  • GNB3

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Лучшие сделки 2021 года

Используйте наши коды скидок Только до 30 ноября!

CYBER MONDAY

Используйте наши коды скидок

Только до 30 ноября!

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