Alfentanil (Efficacy)

Alfentanil is a commonly used fentanyl-derived opioid analgesic and anesthetic. It has been shown that polymorphisms in the OPRM1 gene may be associated with a worse response to these opioid drugs.

Alfentanil is an opiate analgesic with a very rapid onset of action and short duration, derived from fentanyl (alfentanil presents 25% of fentanyl potency).

It is used as a supplement to anesthesia in neuroleptoanalgesia, in short-term and ambulatory surgery. It is also used as a general anesthetic inducer in combination with O2/NO.


Hypersensitivity to morphinomimetics.


Precautions should be taken when prescribing alfentanil to patients with uncontrolled hypothyroidism, pulmonary disease, decreased respiratory reserve, alcoholism and impaired hepatic or renal function.

In patients with compromised intracerebral compliance, caution should be exercised and rapid bolus injection avoided.

In the elderly, lower doses of alfentanil should be prescribed. Patients on chronic treatment with opioids or with dependence require a higher dose of alfentanil. Alfentanil may produce respiratory depression, muscle rigidity, non-epileptic myoclonic movements, bradycardia, hypotension.


Euphoria, movement and visual disorders, vertigo, sedation, dyskinesia, bradycardia and tachycardia, hypotension and hypertension. Apnea. Nausea, vomiting. Muscular stiffness. Fatigue, chills, pain at the injection site.


Alfentanil can produce respiratory depression that is enhanced by: barbiturates, benzodiazepines, neuroleptics, halogenated gases and other central nervous system depressants; in these cases the dose of alfentanil should be reduced.

The metabolism of alfentanil is inhibited by: CYP3A4 inhibitors (fluconazole, voriconazole, erythromycin, diltiazem and cimetidine, ketoconazole, itraconazole, ritonavir); If taking alfentanil concomitantly with these substances the dose of alfentanil should be reduced.

The effect of alfentanil is potentiated by concomitance with MAOIs; do not use alfentanil if you have been treated with MAOIs in the previous 2 weeks.

Alfentanil increases blood levels of propofol.


  • Limifen ®

Genes analyzed


Haven't you taken a DNA test yet?

Get your genetic test and find out all about yourself.


Ancestry, Traits and Wellness


Health, Ancestry, Traits and Wellness

The DNA test you were looking for