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Gabapentin (Efficacy)

Gabapentin is a drug prescribed in the preventive treatment of migraines and chronic headaches, as well as to treat other pathologies such as epilepsy and restless legs syndrome. It is also used to treat neuropathic disorders such as fibromyalgia.

ACTION MECHANISM

The exact mechanism of action of gabapentin is still unknown, but it appears that it exerts its action in neuropathic pain through its binding to N-type voltage gated calcium channels located in the central nervous system, specifically through its binding to the α2δ subunit of these channels.

SIDE EFFECTS

 Gabapentin may cause the following side effects: drowsiness, weakness or tiredness, dizziness, headache, trembling of any part of the body, blurred or double vision, instability, anxiety, memory problems, nausea, vomiting, heartburn, diarrhea, dry mouth, constipation, increased appetite, weight gain, swelling of the hands, feet, ankles or calves, back or joint pain, fever, sneezing, coughing, sore throat or flu-like symptoms, earache, red and itchy eyes (sometimes with swelling or discharge).

BRAND NAMES

 Neurontin®

 Gabmylan®

Gabatur®

Gene or region studied

  • LAT1
  • OCTN1
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