Palonosetron (Efficacy)

Palonosetron is used for the prevention and treatment of chemotherapy-induced nausea and vomiting. This antiemetic drug acts as a serotonin (5-HT3) receptor antagonist. Several clinical studies have observed that the greater or lesser speed with which the drug is metabolized and degraded is related to the pharmacogenetics of the CYP2D6 gene, a cytochrome directly involved in its metabolism.

Palonosetron is an anti-emetic drug (reduces nausea and vomiting) that has recently been approved by the FDA ("Food and Drugs Administration Agency"). It is often used to treat the symptoms of nausea after chemotherapy.

This antiemetic drug acts as a selective high affinity antagonist of the serotonin (5-HT3) receptor.

The most common side effects are headache (9%), constipation (5%), dizziness and diarrhea. There is a risk of serotonergic syndrome if palonosetron is administered concomitantly with SSRI and NRTI drugs.


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